Methyl 4-amino-3-bromobenzoate
Uses- Product Name
- Methyl 4-amino-3-bromobenzoate
- CAS No.
- 106896-49-5
- Chemical Name
- Methyl 4-amino-3-bromobenzoate
- Synonyms
- 4-aMino-3-broMobenzoate;Methyl 4-amino-3-bromoben;METHYL 4-AMINO-3-BROMOBENZOATE;Methyl-3-bromo-4-aminobenzoate;Methyl4-Amino-3-bromobenzoate>Methyl 4-amino-3-bromobenzoate 98%;Methyl 4-amino-3-bromobenzoate,98%;2-Bromo-4-(methoxycarbonyl)aniline;Methyl 4-amino-3-bromobenzoate, GC 98%;Methyl 4-AMino-3-broMobenzoate, 98.0%(GC)
- CBNumber
- CB0482291
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 106896-49-5.mol
Methyl 4-amino-3-bromobenzoate Property
- Melting point:
- 105-109 °C
- Boiling point:
- 334.2±22.0 °C(Predicted)
- Density
- 1.6270 (rough estimate)
- refractive index
- 1.6120 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.41±0.10(Predicted)
- form
- Crystalline Powder
- color
- Brown
- InChI
- InChI=1S/C8H8BrNO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3
- InChIKey
- AIUWAOALZYWQBX-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(N)C(Br)=C1
- CAS DataBase Reference
- 106896-49-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36-36/37/38
- Safety Statements
- 26-36/37-37/39
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29163100
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 655910
- Product name
- Methyl 4-amino-3-bromobenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- 655910
- Product name
- Methyl 4-amino-3-bromobenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $53.8
- Updated
- 2023/06/20
- Product number
- M2084
- Product name
- Methyl 4-Amino-3-bromobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- M2084
- Product name
- Methyl 4-Amino-3-bromobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- M328390
- Product name
- Methyl 4-Amino-3-bromobenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
Methyl 4-amino-3-bromobenzoate Chemical Properties,Usage,Production
Uses
Methyl 4-amino-3-bromobenzoate is a carboxylic acid derivative and a commonly used pharmaceutical and chemical intermediate.
Chemical Properties
brown crystalline powder
Synthesis
619-45-4
106896-49-5
General procedure for the preparation of methyl 4-amino-3-bromobenzoate: methyl 4-aminobenzoate (17 g, 0.1 mol) was dissolved in chloroform (250 mL). N-bromosuccinimide (20 g, 0.1 mol) was added slowly at 0 °C and the reaction mixture was stirred continuously for 3 h at this temperature. After completion of the reaction, the solvent was removed by distillation. Ethyl acetate (100 mL) was added to the residue for dissolution. Subsequently, the mixture was washed with aqueous sodium chloride to remove water-soluble impurities. The organic layer was separated and dried with anhydrous magnesium sulfate. After filtration, the product was purified by recrystallization from hexane to give the final methyl 4-amino-3-bromobenzoate (24.3 g, 93% yield). [1368] NMR data: 1H-NMR (CDCl3) δ 8.11 (1H, d), 7.79-7.77 (1H, m), 6.72 (1H, d), 4.51 (2H, br s), 3.85 (3H, s).
References
[1] Journal of Organic Chemistry, 2014, vol. 79, # 21, p. 10410 - 10416
[2] Patent: WO2010/93191, 2010, A2. Location in patent: Paragraph 1365-1368
[3] Organic Letters, 2015, vol. 17, # 12, p. 2886 - 2889
[4] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2930 - 2936
[5] Synthesis (Germany), 2013, vol. 45, # 11, p. 1497 - 1504
Methyl 4-amino-3-bromobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-amino-3-bromobenzoate manufacturers
- Product
- Methyl 4-amino-3-bromobenzoate 106896-49-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Methyl 4-amino-3-bromobenzoate 106896-49-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11