1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
- Product Name
- 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
- CAS No.
- 637336-53-9
- Chemical Name
- 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
- Synonyms
- Methyl 4-aMino-1-Methyl-1h-pyrazole-3-carboxylate;1-Methyl-4-amino-1H-pyrazol-3-carboxylic acid methyl ester;Methyl 4-Amino-1-methylpyrazole-3-carboxylate;methyl 4-amino-1-methyl-2,3-dihydro-1H-pyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 4-amino-1-methyl-, methyl ester;1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
- CBNumber
- CB11289335
- Molecular Formula
- C6H9N3O2
- Formula Weight
- 155.15
- MOL File
- 637336-53-9.mol
1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Property
- Melting point:
- 99-104 °C(Solv: cyclohexane (110-82-7))
- Boiling point:
- 288.6±20.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 1.28±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C6H9N3O2/c1-9-3-4(7)5(8-9)6(10)11-2/h3H,7H2,1-2H3
- InChIKey
- UBOGPSNFKMAOPP-UHFFFAOYSA-N
- SMILES
- N1(C)C=C(N)C(C(OC)=O)=N1
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M328580
- Product name
- Methyl4-amino-1-methyl-1H-pyrazole-3-carboxylate
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR902301
- Product name
- Methyl4-amino-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- V7048
- Product name
- Methyl4-amino-1-methyl-1h-pyrazole-3-carboxylate
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- V7048
- Product name
- Methyl4-amino-1-methyl-1h-pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- OR902301
- Product name
- Methyl4-amino-1-methyl-1H-pyrazole-3-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Chemical Properties,Usage,Production
Synthesis
400877-57-8
637336-53-9
General procedure for the synthesis of methyl 1-methyl-4-aminopyrazole-3-carboxylate from ethyl 1-methyl-4-nitropyrazole-3-carboxylate: a mixture of methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (500 mg, 2.7 mmol) and 10% palladium carbon (50 mg) in methanol (25 mL) was placed in a Parr reactor at 60 psi of hydrogen pressure for 24 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol. The filtrate was concentrated under reduced pressure to afford methyl 1-methyl-4-amino-1H-pyrazole-3-carboxylate (402 mg, 96% yield) as an off-white solid.
References
[1] Patent: US2004/14766, 2004, A1
[2] Patent: WO2003/106459, 2003, A1. Location in patent: Page 162
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 979 - 984
[4] Patent: US2010/63106, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: WO2017/15449, 2017, A1. Location in patent: Page/Page column 157
1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) manufacturers
- Product
- methyl 4-amino-1-methylpyrazole-3-carboxylate 637336-53-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09