ChemicalBook > CAS DataBase List > 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)

1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)

Product Name: 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
CAS No.: 637336-53-9
Chemical Name: 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
Synonyms: Methyl 4-aMino-1-Methyl-1h-pyrazole-3-carboxylate;1-Methyl-4-amino-1H-pyrazol-3-carboxylic acid methyl ester;Methyl 4-Amino-1-methylpyrazole-3-carboxylate;methyl 4-amino-1-methyl-2,3-dihydro-1H-pyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 4-amino-1-methyl-, methyl ester;1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
CBNumber: CB11289335
Molecular Formula: C6H9N3O2
Formula Weight: 155.15
MOL File: 637336-53-9.mol

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1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Property

Melting point:: 99-104 °C(Solv: cyclohexane (110-82-7))
Boiling point:: 288.6±20.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 1.28±0.10(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C6H9N3O2/c1-9-3-4(7)5(8-9)6(10)11-2/h3H,7H2,1-2H3
InChIKey: UBOGPSNFKMAOPP-UHFFFAOYSA-N
SMILES: N1(C)C=C(N)C(C(OC)=O)=N1

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M328580
Product name: Methyl4-amino-1-methyl-1H-pyrazole-3-carboxylate
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR902301
Product name: Methyl4-amino-1-methyl-1H-pyrazole-3-carboxylate
Purity: 98%
Packaging: 250mg
Price: $131
Updated: 2021/12/16

AK Scientific

Product number: V7048
Product name: Methyl4-amino-1-methyl-1h-pyrazole-3-carboxylate
Packaging: 250mg
Price: $117
Updated: 2021/12/16

AK Scientific

Product number: V7048
Product name: Methyl4-amino-1-methyl-1h-pyrazole-3-carboxylate
Packaging: 1g
Price: $224
Updated: 2021/12/16

Apolloscientific

Product number: OR902301
Product name: Methyl4-amino-1-methyl-1H-pyrazole-3-carboxylate
Purity: 98%
Packaging: 1g
Price: $232
Updated: 2021/12/16

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1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Chemical Properties,Usage,Production

Synthesis

400877-57-8

637336-53-9

General procedure for the synthesis of methyl 1-methyl-4-aminopyrazole-3-carboxylate from ethyl 1-methyl-4-nitropyrazole-3-carboxylate: a mixture of methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate (500 mg, 2.7 mmol) and 10% palladium carbon (50 mg) in methanol (25 mL) was placed in a Parr reactor at 60 psi of hydrogen pressure for 24 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol. The filtrate was concentrated under reduced pressure to afford methyl 1-methyl-4-amino-1H-pyrazole-3-carboxylate (402 mg, 96% yield) as an off-white solid.

References

[1] Patent: US2004/14766, 2004, A1
[2] Patent: WO2003/106459, 2003, A1. Location in patent: Page 162
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 979 - 984
[4] Patent: US2010/63106, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: WO2017/15449, 2017, A1. Location in patent: Page/Page column 157

1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) manufacturers

Career Henan Chemical Co

Product: methyl 4-amino-1-methylpyrazole-3-carboxylate 637336-53-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

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637336-53-9

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