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METHYL 4-AMINOSALICYLATE

Product Name
METHYL 4-AMINOSALICYLATE
CAS No.
4136-97-4
Chemical Name
METHYL 4-AMINOSALICYLATE
Synonyms
pasmethylester;4-AMINOSALICYLATE;THYL 4-AMINOSALICYLATE;methylp-aminosalicylate;Methdilazine Impurity 1;METHYL 4-AMINOSALICYLATE;P-AMINO METHYL SALICYLATE;4-AMINOSALICYLICMETHYLESTER;4-AMINOSALICYLIC ACID ESTER;Methyl4-aminosalicylate,97%
CBNumber
CB2348357
Molecular Formula
C8H9NO3
Formula Weight
167.16
MOL File
4136-97-4.mol
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METHYL 4-AMINOSALICYLATE Property

Melting point:
120-123°C
Boiling point:
120 °C
Density 
1.305±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.81±0.10(Predicted)
form 
Powder
color 
White to Pale Beige
Water Solubility 
Slightly soluble in water.
λmax
254nm(lit.)
CAS DataBase Reference
4136-97-4(CAS DataBase Reference)
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Safety

RTECS 
VO1683000
HazardClass 
IRRITANT
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2508
Product name
Methyl 4-Amino-2-hydroxybenzoate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100 mg
Price
$627
Updated
2025/07/31
TCI Chemical
Product number
M2699
Product name
Methyl 4-Aminosalicylate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$73
Updated
2025/07/31
Usbiological
Product number
455441
Product name
Methyl 4-aminosalicylate
Packaging
500mg
Price
$305
Updated
2021/12/16
TRC
Product number
M328665
Product name
Methyl 4-Aminosalicylate
Packaging
2.5g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR8934
Product name
Methyl4-amino-2-hydroxybenzoate
Purity
97%
Packaging
25g
Price
$73
Updated
2021/12/16
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METHYL 4-AMINOSALICYLATE Chemical Properties,Usage,Production

Uses

Methyl 4-aminosalicylate is used as pharmaceutical intermediate.

Definition

ChEBI: P-Aminosalicylic acid methyl ester is an aromatic amine.

Synthesis

13684-28-1

4136-97-4

Step 2: Preparation of methyl 4-amino-2-hydroxybenzoate In a 500 mL Parr reactor, methyl 2-hydroxy-4-nitrobenzoate (1.3 g, 6.59 mmol) was mixed with a suspension formed by 10% Pd/C catalyst (100 mg) in methanol (40 mL). The reaction mixture was shaken for 1 h under hydrogen atmosphere (30 psi). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. Methyl 4-amino-2-hydroxybenzoate was obtained as a yellow solid (1.08 g, 6.46 mmol, 98% yield). The product was analyzed by UPLC-MS showing 100% purity and the mass spectrum (MS/ESI+) showed a molecular ion peak [MH]+ of 167.9.

References

[1] ACS Catalysis, 2014, vol. 4, # 6, p. 1777 - 1782
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 20, p. 3597 - 3600
[3] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0432; 0434
[4] Journal of the Chemical Society, 1949, p. 1498,1502
[5] Proceedings - Indian Academy of Sciences, Section A, 1950, vol. 32, p. 357,362

METHYL 4-AMINOSALICYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Methyl 4-acetamido-2-methoxybenzoate METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
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METHYL 4-AMINOSALICYLATE Suppliers

Americas 1 China 178 Europe 3 Germany 2 India 5 Japan 1 Ukraine 1 United Kingdom 5 United States 18 Global 214
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from METHYL 4-AMINOSALICYLATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl 4-amino-2-hydroxybenzenecarboxylate 4136-97-4
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-09-14
Hebei Chuanghai Biotechnology Co., Ltd
Product
METHYL 4-AMINOSALICYLATE 4136-97-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-04
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
METHYL 4-AMINOSALICYLATE 4136-97-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-06

4136-97-4, METHYL 4-AMINOSALICYLATERelated Search:

Methyl 4-amino-2-methoxybenzoate Methyl 4-amino-3-bromobenzoate 1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) Methyl 4-amino-3-methylbenzoate Methyl-4-amino-3-fluorobenzoate Methyl 4-amino-2-chlorobenzoate Methyl 4-amino-3-bromo-5-fluorobenzoate Methyl-4-amino-3-bromo-5-methylbenzoate Methyl 4-amino-3-methoxybenzoate Methyl4-amino-2-methylbenzoate METHYL PENTAFLUOROBENZOATE Methyl p-nitrophenylacetate METHYL 3-(4-METHOXYPHENYL)PROPIONATE Methyl 4-acetamido-5-chloro-2-methoxybenzoate Ethopabate Methyl 4-acetamido-2-methoxybenzoate METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Hydroxytetracaine

  • METHYL 4-AMINOSALICYLATE
  • METHYL 4-AMINO-2-HYDROXYBENZENECARBOXYLATE
  • Methyl 4-aminosalicylate, 3-Hydroxy-4-(methoxycarbonyl)aniline, 5-Amino-2-(methoxycarbonyl)phenol
  • Methyl 4-amino-2-hydroxybenzoate 97%
  • Benzoic acid,4-aMino-2-hydroxy-, Methyl ester
  • Methyl 4-aMino-2-hydroxybenzenecarboxylate, >95%
  • 4-AMINOSALICYLATE
  • 4-amino-2-hydroxybenzenecarboxyL
  • P-AMINO METHYL SALICYLATE
  • 4-amino-2-hydroxy-benzoicacimethylester
  • amino-salicylicacimethylester
  • methylp-aminosalicylate
  • p-aminosalicylicacidmethylester
  • pasmethylester
  • 4-Aminosalicylic Acid Methyl Ester
  • 4-AMINOSALICYLICMETHYLESTER
  • 4-AMINOSALICYLIC ACID ESTER
  • METHYL 4-AMINO-2-HYDROXYBENZOATE
  • 2-Hydroxy-4-aminobenzoic acid methyl ester
  • 4-Amino-2-hydroxybenzoic acid methyl ester
  • methyl 4-azanyl-2-hydroxy-benzoate
  • Methyl 4-Aminosalicylate &gt
  • Methyl4-aminosalicylate,97%
  • Aminosalicylic acid methyl ester
  • THYL 4-AMINOSALICYLATE
  • Methdilazine Impurity 1
  • Methyl 4-amino-2-hydroxybenzoat
  • 4136-97-4