ChemicalBook > CAS DataBase List > 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
- Product Name
- 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
- CAS No.
- 118414-59-8
- Chemical Name
- 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
- Synonyms
- NTZDPA;5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid;5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID;1H-Indole-2-carboxylic acid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-
- CBNumber
- CB1224807
- Molecular Formula
- C22H15Cl2NO2S
- Formula Weight
- 428.33
- MOL File
- 118414-59-8.mol
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5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Property
- storage temp.
- Store at +4°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
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Safety
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0616
- Product name
- nTZDpa
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0616
- Product name
- nTZDpa
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $484
- Updated
- 2023/06/20
TRC
- Product number
- C365800
- Product name
- 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylicAcid
- Packaging
- 50mg
- Price
- $635
- Updated
- 2021/12/16
Usbiological
- Product number
- 256070
- Product name
- nTZDpa
- Packaging
- 10mg
- Price
- $432
- Updated
- 2021/12/16
Chemenu
- Product number
- CM267890
- Product name
- 5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
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5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.
Biological Activity
Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .
storage
Store at +4°C
5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Suppliers
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118414-59-8, 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACIDRelated Search:
5-CHLORO-3-(PHENYLTHIO)-INDOLE
5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
1-PHENYLMETHYL-1H-INDOLE-2-METHANOL