Description Biological functions Synthesis
ChemicalBook > CAS DataBase List > FMRF AMIDE

FMRF AMIDE

Description Biological functions Synthesis
Product Name
FMRF AMIDE
CAS No.
64190-70-1
Chemical Name
FMRF AMIDE
Synonyms
FMRF-NH2;MFRF amide;FMRF AMIDE;neuropeptide C;PHE-MET-ARG-PHE-NH2;PHE-MET-ARG-PHE AMIDE;H-PHE-MET-ARG-PHE-NH2;L-Phe-L-Met-L-Arg-Phe-NH2;FMRF-AMIDE 1 1/2ACOH 2H2O;L-Phe-L-Met-L-Arg-L-Phe-NH2
CBNumber
CB1231122
Molecular Formula
C29H42N8O4S
Formula Weight
598.76
MOL File
64190-70-1.mol
More
Less

FMRF AMIDE Property

Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in DMSO
pka
13.35±0.46(Predicted)
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Usbiological
Product number
F5600-05F
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05H
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05J
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
F5600-05K
Product name
FMRF amide
Packaging
1mg
Price
$531
Updated
2021/12/16
More
Less

FMRF AMIDE Chemical Properties,Usage,Production

Description

FMRFamide (FMRFa) was originally isolated as a cardioacceleratory peptide from mollusks. To date, a number of biologically active FMRFas and their related peptides have been identified. 

Biological functions

Target cells and function The predominant effect of FaRPs is the reduction of spontaneous muscle contractions, such as in the intestinal muscle and the heart rate. Among FaRP subtypes, some FaRPs function in gut contraction and other subtypes do not. Physiological discrimination according to different subtype of FaRPs results in extensive functions.For example, FaRPs exert acceleratory effects on the heart rate, inhibitory effects on gut motility, and modulate synaptic activity. Furthermore, sequential ecdysis behavior is also regulated by FaRPs, consequently activating the downstream of the eclosion hormone (EH) and ecdysistriggering hormone (ETH).During ecdysis, FaRP-expressing Tv neurons are activated by ETH.

Synthesis

Gene, mRNA, and precursor D. melanogaster FMRFa mRNA produces a deduced prepropeptide composed of 347 aa. The prepropeptide is composed of a signal sequence, and 10 copies of FMRFa and extended FaRPs. The mature peptides are processed proteolytically and amidated at each C-terminal of the peptides.

FMRF AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

FMRF AMIDE Suppliers

China 15 France 1 Germany 3 Japan 2 Switzerland 1 United Kingdom 3 United States 13 USA 1 Global 39
chemcube
Tel
--
Fax
--
Email
sales@chemcube.eu
Country
Germany
ProdList
4083
Advantage
34
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
BIOTREND Chemikalien GmbH
Tel
--
Fax
--
Email
jaeger@biotrend.com
Country
Germany
ProdList
6115
Advantage
76

64190-70-1, FMRF AMIDERelated Search:

[D-MET2]-FMRF-AMIDE FMRF amide (AF-1) (Lys-Asn-Glu-Phe-Ile-Arg-Phe-NH2) FMRF amide (AF-2) (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) FMRF amide (Phe-Met-Arg-Phe-NH2) (Molluscan Cardioexcitatory Neuropeptide) FMRF amide [D-Phe1] (D-Phe-Met-Arg-Phe-NH2) FMRF amide [D-Met2] (Phe-D-Met-Arg-Phe-NH2) FMRF amide-like Peptide I (lobster) (Ser-Asp-Arg-Asn-Phe-Leu-Arg-Phe-NH2) FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE,FMRF-AMIDE 1 1/2ACOH 2H2O,FMRF AMIDE FMRF AMIDE-LIKE PEPTIDE II, LOBSTER FMRF amide [D-Arg3] (Phe-Met-D-Arg-Phe-NH2) FMRF amide [D-Phe4] (Phe-Met-Arg-D-Phe-NH2) FMRF-AMIDE LIKE PEPTIDE 1 (LOBSTER),FMRF AMIDE-LIKE PEPTIDE I, LOBSTER FMRF amide (Nle-Arg-Phe-NH2) FMRF amide (Leu-Ser-Ser-Phe-Val-Arg-Ile-NH2) FMRF amide (Phe-Leu-Arg-Arg) FMRF amide (Tyr-Phe-Met-Arg-Phe-NH2) FMRF amide (Trp-Nle-Arg-Phe-NH2) FMRF amide (Met-Arg-Phe)

  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O
  • MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • PHE-MET-ARG-PHE AMIDE
  • PHE-MET-ARG-PHE-NH2
  • PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
  • 6-O-?D-Glucopyranosyl-D-glucitol
  • L-PHENYLALANYL-L-METHIONYL-L-ARGINYL-L-PHENYLALANINAMIDE)
  • neuropeptide C
  • FMRF amide, Molluscan cardioexcitatory neuropeptide
  • L-Phe-L-Met-L-Arg-L-Phe-NH2
  • L-Phe-L-Met-L-Arg-Phe-NH2
  • MFRF amide
  • (2S)-N-[(1S)-2-amino-1-(benzyl)-2-keto-ethyl]-2-[[2-[[(2S)-2-amino-3-phenyl-propanoyl]amino]-4-(methylthio)butanoyl]amino]-5-guanidino-valeramide
  • (2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanamide
  • (2S)-N-[(2S)-1-azanyl-1-oxo-3-phenyl-propan-2-yl]-2-[[2-[[(2S)-2-azanyl-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanamide
  • Cardioexcitatory peptide (mollusk)
  • Neuropeptide C (Macrocallista nimbosa cardioexcitatory)
  • FMRF AMIDE
  • FMRF-AMIDE 1 1/2ACOH 2H2O
  • FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • FMRF-NH2
  • H-PHE-MET-ARG-PHE-NH2
  • Phe-Met-Arg-Phe amide, ≥95% (HPLC)
  • L-Phenylalaninamide,L-phenylalanyl-L-methionyl-L-arginyl-
  • (S)-N-((S)-1-Amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-4-(methylthio)butanamido)-5-guanidinopentanamide
  • 64190-70-1
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Other Neuropeptides
  • Peptides
  • Invertebrate Neuropeptides