ChemicalBook > CAS DataBase List > 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

Product Name: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
CAS No.: 102691-36-1
Chemical Name: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
Synonyms: P-REAGENT;2-CYANOETHYL TETRAISOPROPYLPHOSPHORODIAMIDITE;3-Bis(diisopropylamino)phosphanyloxypropanenitrile;3-(bis(diisopropylamino)phosphinooxy)propanenitrile;THERAPEUTIC GRADE PHOS REAGENT;BIS(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINE;94.0%(GC&phosphordiamidit;Phosphorus reagent B;Phosphorous reagent A
CBNumber: CB1231672
Molecular Formula: C15H32N3OP
Formula Weight: 301.41
MOL File: 102691-36-1.mol

Less

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Property

Boiling point:: 100 °C0.5 mm Hg(lit.)
Density: 0.949 g/mL at 25 °C(lit.)
refractive index: n20/D 1.470(lit.)
Flash point:: 141 °F
storage temp.: -20°C
solubility: Acetonitrile (Slightly), Benzene, Chloroform (Sparingly), Methanol (Slightly)
form: liquid
pka: 6.78±0.70(Predicted)
color: colorless
Sensitive: moisture sensitive, store cold
BRN: 3590103
Stability:: Explodes When Heated
InChIKey: RKVHNYJPIXOHRW-UHFFFAOYSA-N
LogP: 4.04 at 20℃
CAS DataBase Reference: 102691-36-1(CAS DataBase Reference)
EPA Substance Registry System: Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester (102691-36-1)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 5-36/37/38-42/43-36/38
Safety Statements: 3-26-36-24/25-23-45-36/37
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
F: 10-21-34
Hazard Note: Irritant/May Explode on Heating
HazardClass: 8
PackingGroup: I
HS Code: 29299000

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 305995
Product name: 2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite
Purity: 97%
Packaging: 1g
Price: $88.92
Updated: 2025/07/31

Sigma-Aldrich

Product number: 305995
Product name: 2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite
Purity: 97%
Packaging: 5g
Price: $196
Updated: 2025/07/31

TCI Chemical

Product number: C2228
Product name: 2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphordiamidite
Purity: >95.0%(GC)(T)
Packaging: 1g
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: C2228
Product name: 2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphordiamidite
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $189
Updated: 2025/07/31

Strem Chemicals

Product number: 15-0695
Product name: 2-Cyanoethyl N,N,N',N'-tetra(i-propyl)phosphorodiamidite, min. 98%
Packaging: 1g
Price: $60
Updated: 2024/03/01

Less

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Chemical Properties,Usage,Production

Description

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is a colorless viscous liquid, which is soluble in most organic solvents. It is a widely used phosphitylating reagent for the preparation of various phosphorylated biomolecules, such as nucleoside carbohydrate conjugates, phospholipids and glycopeptides. In particular, this reagent is highly effective for automated solid-phase DNA/RNA oligonucleotide synthesis. It has shown great utility in the coupling of nucleobases or carbohydrates via their phosphotriesters in the presence of activators such as 1H-tetrazole, in moderate yields under mild conditions.This compound is cheaper and more stable than 2-cyanoethyl N,N-diisopropylchlorophosphorodiamidite (the other commonly used phosphinylating reagent)[1].

Chemical Properties

Clear to Cloudy Colourless Liquid

Uses

Reagent for synthesizing phosphitylated nucleotides.1

Uses

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite was used:

in preparation of prosphoramidite reagent, required for synthesis of 12-mer oligodeoxynucleotide
as phosphorylating agent in synthesis of 1,2-diacyl-sn-glycerophosphatidylserine
in situ preparation of deoxyribonucleoside phosphoramidites
in preparation of 2′-deoxy-2′-fluoro-3′-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-5′-O-(4-methoxytrityl)-4′-thio-β-D-arabinouridine and 1-(3-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-2-deoxy-2-fluoro-5-O-(4,4′-dimethoxytrityl)-4-thio-β-D-arabinofuranosyl)-thymine
as reagent for synthesizing phosphitylated nucleotides

Application

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is an important organic reagent widely used in the preparation of modified and unmodified nucleoside phosphoramidites. Nucleoside phosphoramidites are ideal reagents for polymer-supported synthesis of oligonucleotides. The diisopropylamino leaving group is readily cleaved upon contact with the azole catalyst, resulting in an efficient coupling reaction with the free hydroxyl group on the protected nucleoside.

Synthesis

3-((dichlorophosphaneyl)oxy)propanenitrile could synthesize 2-Cyanoethyl N, N, N', N'-tetraisopropylphosphorodiamidite with diisopropylamine. This method is inexpensive manner using a two-step, one-pot procedure and purified by vacuum distillation[2].

References

[1] Hada N, et al. Synthetic studies on glycosphingolipids from Protostomia phyla: syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi. Carbohydrate Research, 2008; 343: 343, 2221.
[2] Ching S, et al. Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase. Bioorganic & Medicinal Chemistry, 2010; 18: 6657-6665.

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Preparation Products And Raw materials

Raw materials

Preparation Products

Ceftibuten anionic starch

Less

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Suppliers

Americas 1 Belgium 1 Canada 4 China 333 Europe 3 France 3 Germany 6 India 14 Italy 1 Japan 5 Switzerland 4 Ukraine 1 United Kingdom 17 United States 50 Global 443

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Xinxiang Runyu Material Co., Ltd.

Tel: 166-166-37336996 15690792173
Fax: 0373-7759608
Email: chenxi.song@runvmat.com
Country: China
ProdList: 285
Advantage: 55

Bengbu Nako Chemical Co., Ltd.

Tel: 0552-3068102 13966060073
Fax: 0552-3068843
Email: sales@nakochem.com
Country: China
ProdList: 26
Advantage: 58

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 553-553-2911116-803-803 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 305
Advantage: 58

Nugene Biopharm Science (Hangzhou) Co., Ltd.

Tel: 13326014885
Email: service@nugene.com.cn
Country: China
ProdList: 55
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Lianhe Aigen Pharmatech Co.,Ltd.

Tel: 18918657159
Email: sales-Aigen@lianhetech.com
Country: China
ProdList: 3000
Advantage: 58

Chongqing Botao Biotechnology Co., LTD

Tel: 15223382610
Email: danny@chemdad.com
Country: China
ProdList: 2032
Advantage: 58

Shanghai Thoreco Novel Material Co. Ltd

Tel: 021-34202258 17317865669;
Email: Sales@thoreco.com
Country: China
ProdList: 183
Advantage: 58

Shanghai Xianggeng Technology Development Co. Ltd.

Tel: 021-021-56152668 18116302010
Fax: 18116300787
Email: sharing@sharingtechcn.com
Country: China
ProdList: 506
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Beijing VSciChem Technology Co., Ltd.

Tel: 13811761079
Email: vscichem@163.com
Country: China
ProdList: 263
Advantage: 64

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-5842013-801 18155347026
Fax: 086-553-5843138
Email: jinhuaren@huarensh.com
Country: China
ProdList: 255
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Springchem New Material Technology Co.,Limited

Tel: +86-021-62885108 +8613917661608
Email: info@spring-chem.com
Country: China
ProdList: 2068
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Changzhou Joyous Chemical Co., Ltd.

Tel: 0519-85607258 13912342323;
Fax: 0519-85607278
Email: sales@joyouschem.com
Country: China
ProdList: 294
Advantage: 60

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Anhui nuoquan pharmaceutical co. LTD

Tel: 15705561919
Fax: 0556-5032869
Email: chunli.yi@nuozhanchem.com
Country: China
ProdList: 101
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2327
Advantage: 58

ShangHai Zexin Chemical Technology Co., Ltd.

Tel: 021-60136491 15901897992
Fax: 021-60136492
Country: China
ProdList: 455
Advantage: 55

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai D&B Biological Science and Technology Co.Ltd

Tel: 400-008-9730,021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3057
Advantage: 60

Sinocompound Catalysts Co., Ltd.

Tel: 0512-67216630 67216634
Fax: 0512-56316689
Email: sales@sinocompound.com
Country: China
ProdList: 271
Advantage: 64

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 023-13650506873 19923294409
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1604
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Less

View Lastest Price from 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 102691-36-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min PNMR
Supply Ability: 10KG
Release date: 2021-06-08

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 102691-36-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Anhuyan (Hainan) Biotechnology Co., LTD

Product: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 102691-36-1
Price: US $0.00/G/KG
Min. Order: 1G/KG
Purity: 99%
Supply Ability: 10000000KG
Release date: 2025-02-12

102691-36-1, 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamiditeRelated Search:

Bis[3-(triethoxysilyl)propyl]tetrasulfide Bis(triethoxysilylpropyl) disulfide N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos Diisopropylamine Minoxidil (Chloromethylene)dimethyliminium chloride Lithium diisopropylamide DIETHOXYMETHANE Ethoxymethylenemalononitrile LITHIUM PERIODATE Ethoxyquin BLOCKING REAGENT GE 4-Ethoxyphenol Bis(2-methyl-3-furyl)disulfide (3R,5S)-3,5-DiMethylMorpholine hydrochloride Bis(4-chlorobenzyl) azodicarboxylate Bis(4-tert-butylcyclohexyl) peroxydicarbonate Phosphine

P-REAGENT

2-Cyanoethoxybis(N,N-diisopropylaMino)phosphine

Bis(diisopropylaMino)(2-cyano

N,N,N',N'-Tetrakis(1-Methylethyl)phosphorodiaMidous Acid 2-Cyanoethyl Ester

THERAPEUTIC GRADE PHOS REAGENT

2-Cyanoethyl N,N,N',N'-tetra(prop-2-yl)phosphorodiamidoite

2-Cyanoethyl N,N,N',N'-tetrakis(isopropyl)phosphorodiamidite

2-CYANOETHYLTETRAISOPROPYLPHOSPHORO-DIA

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 97%

2-Cyanoethyl N,N,N',N'-tetra(i-propyl)phosphorodiamidite

CTPPA 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

Phosphorous reagent A

Phosphorus reagent B

2-CYANOETHYL TETRAISOPROPYLPHOSPHOR

BIS(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINE

β-Cyanoethyl-N,N,N`,N`-tertraisopropylphosphorodia

Bis(diisopropylamino)(2-cyanoethoxy)phosphine P-Reagent

2-Cyanoethyl-N,N',N'-Tetraisopropylphosphordiamidite

2-CYANOETHYL N,N,N',N'-TETRAISOPROPYLPHOSPHORAMIDITE

2-CYANOETHYL TETRAISOPROPYLPHOSPHORODIAMIDITE

Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester

2-CYANOETHYL-N,N,N'',N''-TETRAISO-PROPYLPHOSPHORAMIDITE(P-REAGENT)

b-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite

TETRAISOPROPYLPHOSPHORODIAMIDITE

5) 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite

PHOSPHORODIAMIDOUS ACID, N,N,N'',N''-TETRAKIS(1-METHYLETHYL)-, 2-CYANOETHYL ESTER

2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite 98%

3-(bis(diisopropylamino)phosphinooxy)propanenitrile

2-Cyanoethyl N,N,N',N'-tetra(i-propyl)phosphorodiamidite, min. 98%

2-Cyanoethyl-N,N,Nzzhlxy,Nzzhlxy-tetraisopropylphosphordiamidite (P-Reagent)

2-Cyanoethyl N,N,N',N'-tetrakis(isopropyl)phosphorodiamidite 95+%

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite(CTPPA)

94.0%(GC&amp

2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphordiamidite &gt

N,N,N',N'-tetraisopropyL

phosphordiamidit

2-O-cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite

3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile

3-Bis(diisopropylamino)phosphanyloxypropanenitrile

3-((Bis(diisopropylamino)phosphino)oxy), 97%

β-Cyanoethyl-N,N,N`,N`-tertraisopropylphosphorodiamidite

bis(2-cyano-1,1-dimethylethyl)-N,N-diisopropylphosphoramidite

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphordiamidite

CTPPA2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphorodiamidite

2-Cyano-N,N,N',N'-tetraisopropylphosphorodiamidite

2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (P-Reagent)

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

102691-36-1

102691-30-1

916966-01-5

CH32CH2N2POCH2CH2CN

C15H38N3OP

C15H32N3OP

C15H32N3P