(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
- Product Name
- (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
- CAS No.
- 63038-10-8
- Chemical Name
- (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one
- Synonyms
- Senkyunolide;Sedanenolide;(S)-sencyunolide;(S)-Sedanenolide;(-)-Sedanenolide;3-Butyl-4,5-dihydrophthalide;Senkyunolide A, 10 mM in DMSO;(S)-3-Butyl-4,5-dihydroisobenzofuran-1(3H)-one;(3S)-3-Butyl-4,5-dihydro-1(3H)-isobenzofuranone;1(3H)-Isobenzofuranone, 3-butyl-4,5-dihydro-, (S)-
- CBNumber
- CB12343799
- Molecular Formula
- C12H16O2
- Formula Weight
- 192.26
- MOL File
- 63038-10-8.mol
(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Property
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- form
- Liquid
- color
- Colorless to light yellow
- LogP
- 1.775 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25199
- Product name
- Senkyunolide A
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 25199
- Product name
- Senkyunolide A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 25199
- Product name
- Senkyunolide A
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 25199
- Product name
- Senkyunolide A
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $595
- Updated
- 2024/03/01
- Product number
- 300953
- Product name
- Senkyunolide A
- Packaging
- 20mg
- Price
- $490
- Updated
- 2021/12/16
(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Chemical Properties,Usage,Production
Description
Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and α-synuclein and reverses decreases in the phosphorylated forms of PP2A and α-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 μM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 μM).
Chemical Properties
A slightly yellow oily substance, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Chuanxiong.
Definition
ChEBI: Senkyunolide is a member of 2-benzofurans.
References
[1] LEONARD F. BJELDANES In S K. Phthalide components of celery essential oil[J]. The Journal of Organic Chemistry, 1977, 42 13: 2333-2335. DOI: 10.1021/jo00433a033
[2] SHENGLAN GONG. Senkyunolide A protects corticosterone-induced cell apoptosis via modulating protein phosphatase 2A and α-synuclein[J]. bioRxiv?: the preprint server for biology, 2017, 24 1. DOI: 10.1101/145326
[3] WINNIE LAI TING KAN. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells[J]. Journal of ethnopharmacology, 2008, 120 1: Pages 36-43. DOI: 10.1016/j.jep.2008.07.027
(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
(3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Suppliers
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View Lastest Price from (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one manufacturers
- Product
- Senkyunolide A 63038-10-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 10000
- Release date
- 2025-04-08
- Product
- Senkyunolide A 63038-10-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-28
- Product
- Senkyunolide H 63038-10-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-28