4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID

Product Name: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
CAS No.: 195457-71-7
Chemical Name: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
Synonyms: AKOS BAR-0023;RARECHEM AL BE 1218;4-CARBOXY-4'-TRIFLUOROMETHYLDIPHENYL;4-[4-(trifluoromethyl)phenyl]benzoate;4-(4-(Trifluoromethyl)phenyl)benzoic acid;4'-Trifluoromethylbiphenyl-4-carboxylic acid;4''-TRIFLUOROMETHYL-BIPHENYL-4-CARBOXYLIC ACID, 95+%;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid;[1,1'-Biphenyl]-4-carboxylic acid, 4'-(trifluoroMethyl)-
CBNumber: CB1237609
Molecular Formula: C14H9F3O2
Formula Weight: 266.22
MOL File: 195457-71-7.mol

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4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Property

Melting point:: 120.0-121.1 °C
Boiling point:: 360.8±42.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.04±0.10(Predicted)
color: White to Off-White
CAS DataBase Reference: 195457-71-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T779098
Product name: 4''-(Trifluoromethyl)[1,1''-biphenyl]-4-carboxylicAcid
Packaging: 250mg
Price: $50
Updated: 2021/12/16

TRC

Product number: T779098
Product name: 4''-(Trifluoromethyl)[1,1''-biphenyl]-4-carboxylicAcid
Packaging: 1g
Price: $185
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2821-3-X4
Product name: 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
Purity: 98%
Packaging: 1g
Price: $136
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003040
Product name: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 0.25G
Price: $152
Updated: 2021/12/16

Matrix Scientific

Product number: 071869
Product name: 4'-Trifluoromethyl-biphenyl-4-carboxylic acid
Purity: 95+%
Packaging: 5g
Price: $300
Updated: 2021/12/16

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4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

4''-(Trifluoromethyl)[1,1''-biphenyl]-4-carboxylic Acid is a reagent used in the synthesis of pharmaceuticals and pharmaceutical intermediates

Synthesis

586-76-5

128796-39-4

195457-71-7

The general procedure for the synthesis of 4'-trifluoromethyl-diphenyl-4-carboxylic acid from 4-bromobenzoic acid and 4-trifluoromethylphenylboronic acid was as follows: the reaction was carried out according to General Method D. 4-Bromobenzoic acid (10 g, 49.4 mmol), 4-trifluoromethylphenylboronic acid (14.17 g, 74.61 mmol), tetrakis(triphenylphosphine)palladium (5.7 g, 4.974 mmol) and 2N Na2CO3 aqueous solution (150 mL, 149.2 mmol) were mixed in 500 mL of toluene. Upon completion of the reaction, the reaction mixture was neutralized with 2N HCl and subsequently filtered. The resulting solid was dissolved in ethyl acetate and purified by a short silica gel column to give 9.7 g (75% yield) of the target product 4'-trifluoromethyl-diphenyl-4-carboxylic acid as a white solid.

References

[1] Tetrahedron Letters, 2005, vol. 46, # 34, p. 5751 - 5754
[2] Green Chemistry, 2010, vol. 12, # 1, p. 150 - 158
[3] Patent: WO2004/14844, 2004, A2. Location in patent: Page 179; 181
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 20, p. 4939 - 4952
[5] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3144 - 3150

4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Suppliers

China 54 France 1 Germany 5 India 1 Russia 1 United Kingdom 7 United States 14 Global 83

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View Lastest Price from 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 195457-71-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 195457-71-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 195457-71-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

195457-71-7, 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACIDRelated Search:

3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 2'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID,Trifluoromethylbiphenyl-4-carboxylic acid 3'-TRIFLUOROMETHYLBIPHENYL-3-CARBOXYLIC ACID 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE RARECHEM AL BI 1218 4-(TRIFLUOROMETHYL)-BIPHENYL 4'-METHYL-4-TRIFLUOROMETHYL-BIPHENYL (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID METHYL 4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLATE

AKOS BAR-0023

4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID

4-CARBOXY-4'-TRIFLUOROMETHYLDIPHENYL

4-(4-(Trifluoromethyl)phenyl)benzoic acid

4''-TRIFLUOROMETHYL-BIPHENYL-4-CARBOXYLIC ACID, 95+%

RARECHEM AL BE 1218

[1,1'-Biphenyl]-4-carboxylic acid, 4'-(trifluoroMethyl)-

4-[4-(trifluoromethyl)phenyl]benzoate

4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

4'-Trifluoromethylbiphenyl-4-carboxylic acid

4′-(Trifluoromethyl)-[1,1′-biphenyl]-4-carboxylic acid, CAS 195457-71-7

195457-71-7

pharmacetical

Biphenyl & Diphenyl ether