(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

Product Name: (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL
CAS No.: 457889-46-2
Chemical Name: (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL
Synonyms: AKOS BAR-1788;RARECHEM AL BD 1218;4-(4-Trifluoromethyl)Benzyl Alcohol;4’-(Trifluoromethyl)biphenyl-4-methanol;(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL;1-(4^-Trifluoromethylbiphenyl-4-yl)methanol;4-(4-(Trifluoromethyl)phenyl)benzyl alcohol;[4-[4-(trifluoromethyl)phenyl]phenyl]methanol;4'-(Trifluoromethyl)[1,1'-biphenyl]-4-methanol;4'-(TrifluoroMethyl)-[1,1'-biphenyl]-4-Methanol
CBNumber: CB9152278
Molecular Formula: C14H11F3O
Formula Weight: 252.23
MOL File: 457889-46-2.mol

More

Less

(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Property

Melting point:: 147-149°
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

More

Less

Safety

HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 048642
Product name: [4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol
Purity: >95%
Packaging: 500mg
Price: $172
Updated: 2021/12/16

Matrix Scientific

Product number: 048642
Product name: [4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol
Purity: >95%
Packaging: 1g
Price: $410
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0038382
Product name: [4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-YL]METHANOL
Purity: 95.00%
Packaging: 500MG
Price: $791.52
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0038382
Product name: [4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-YL]METHANOL
Purity: 95.00%
Packaging: 1G
Price: $866.13
Updated: 2021/12/16

Matrix Scientific

Product number: 048642
Product name: [4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol
Purity: >95%
Packaging: 5g
Price: $1320
Updated: 2021/12/16

More

Less

(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Chemical Properties,Usage,Production

Synthesis

195457-71-7

457889-46-2

LiAlH4 (2.0 M THF solution, 3.0 mL, 6.00 mmol) was dissolved in anhydrous THF (10 mL) under nitrogen protection and cooled to 0 °C. To this stirred mixture was added dropwise a solution of 4'-[4-(trifluoromethyl)phenyl]benzoic acid (0.4 g, 1.5 mmol) in anhydrous THF (10 mL). The reaction mixture was stirred at room temperature for 4 hours. Subsequently, H2O (0.23 mL), 3.0 M KOH solution (0.23 mL) and H2O (0.77 mL) were added slowly at 0 °C. The mixture was continued to be stirred at 0 °C for 1 h. The solid residue was removed by filtration and the organic phase was dried with Na2SO4. The organic solution was filtered again and concentrated to dryness. The crude product was purified by column chromatography using a Teledyne ISCO unit with the eluent cyclohexane/ethyl acetate (100:0 to 70:30) to afford 4'-trifluoromethyl-4-biphenylmethanol (0.3 g, 79%) as a white solid.1H NMR (DMSO-d6) data were as follows: δ 4.56 (d, J=5.7 Hz, 2H), δ 5.25 (t, J=5.7Hz, 1H), 7.45 (d, J=8.1Hz, 2H), 7.70 (d, J=8.1Hz, 2H), 7.81 (d, J=8.1Hz, 2H), 7.89 (d, J=8.1Hz, 2H).

References

[1] Patent: WO2013/78430, 2013, A1. Location in patent: Paragraph 0353
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 23, p. 10101 - 10111
[3] Patent: US9353075, 2016, B2. Location in patent: Page/Page column 122
[4] Patent: WO2009/71504, 2009, A1. Location in patent: Page/Page column 65
[5] Patent: WO2010/15653, 2010, A1. Location in patent: Page/Page column 39

(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Suppliers

China 34 France 1 Germany 2 India 1 Russia 1 United Kingdom 1 United States 7 Global 47

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9947
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

457889-46-2, (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOLRelated Search:

4-(TRIFLUOROMETHYL)-BIPHENYL (3'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL (2'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL (2'-TRIFLUOROMETHYLBIPHENYL-3-YL)-METHANOL (3'-TRIFLUOROMETHYLBIPHENYL-3-YL)-METHANOL (4'-TRIFLUOROMETHYLBIPHENYL-3-YL)-METHANOL 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID METHYL 4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLATE RARECHEM AL BI 1218 RARECHEM AL BP 1218 (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

(4-[4-(TRIFLUOROMETHYL)PHENYL]PHENYL)METHAN-1-OL

(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

[4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-YL]METHANOL

AKOS BAR-1788

RARECHEM AL BD 1218

4-(4-Trifluoromethyl)Benzyl Alcohol

4-(4-(Trifluoromethyl)phenyl)benzyl alcohol

1-(4^-Trifluoromethylbiphenyl-4-yl)methanol

[4-[4-(trifluoromethyl)phenyl]phenyl]methanol

4'-(TrifluoroMethyl)-[1,1'-biphenyl]-4-Methanol

4’-(Trifluoromethyl)biphenyl-4-methanol

[1,1'-Biphenyl]-4-methanol, 4'-(trifluoromethyl)-

4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol

4'-(Trifluoromethyl)[1,1'-biphenyl]-4-methanol

[4′-(Trifluoromethyl)[1,1′-biphenyl]-4-yl]methanol, CAS 457889-46-2

457889-46-2

pharmacetical