(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL
- Product Name
- (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL
- CAS No.
- 457889-46-2
- Chemical Name
- (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL
- Synonyms
- AKOS BAR-1788;RARECHEM AL BD 1218;4-(4-Trifluoromethyl)Benzyl Alcohol;4’-(Trifluoromethyl)biphenyl-4-methanol;(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL;1-(4^-Trifluoromethylbiphenyl-4-yl)methanol;4-(4-(Trifluoromethyl)phenyl)benzyl alcohol;[4-[4-(trifluoromethyl)phenyl]phenyl]methanol;4'-(Trifluoromethyl)[1,1'-biphenyl]-4-methanol;4'-(TrifluoroMethyl)-[1,1'-biphenyl]-4-Methanol
- CBNumber
- CB9152278
- Molecular Formula
- C14H11F3O
- Formula Weight
- 252.23
- MOL File
- 457889-46-2.mol
(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Property
- Melting point:
- 147-149°
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 048642
- Product name
- [4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol
- Purity
- >95%
- Packaging
- 500mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- 048642
- Product name
- [4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol
- Purity
- >95%
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- HCH0038382
- Product name
- [4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-YL]METHANOL
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $791.52
- Updated
- 2021/12/16
- Product number
- HCH0038382
- Product name
- [4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-YL]METHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $866.13
- Updated
- 2021/12/16
- Product number
- 048642
- Product name
- [4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol
- Purity
- >95%
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Chemical Properties,Usage,Production
Synthesis
195457-71-7
457889-46-2
LiAlH4 (2.0 M THF solution, 3.0 mL, 6.00 mmol) was dissolved in anhydrous THF (10 mL) under nitrogen protection and cooled to 0 °C. To this stirred mixture was added dropwise a solution of 4'-[4-(trifluoromethyl)phenyl]benzoic acid (0.4 g, 1.5 mmol) in anhydrous THF (10 mL). The reaction mixture was stirred at room temperature for 4 hours. Subsequently, H2O (0.23 mL), 3.0 M KOH solution (0.23 mL) and H2O (0.77 mL) were added slowly at 0 °C. The mixture was continued to be stirred at 0 °C for 1 h. The solid residue was removed by filtration and the organic phase was dried with Na2SO4. The organic solution was filtered again and concentrated to dryness. The crude product was purified by column chromatography using a Teledyne ISCO unit with the eluent cyclohexane/ethyl acetate (100:0 to 70:30) to afford 4'-trifluoromethyl-4-biphenylmethanol (0.3 g, 79%) as a white solid.1H NMR (DMSO-d6) data were as follows: δ 4.56 (d, J=5.7 Hz, 2H), δ 5.25 (t, J=5.7Hz, 1H), 7.45 (d, J=8.1Hz, 2H), 7.70 (d, J=8.1Hz, 2H), 7.81 (d, J=8.1Hz, 2H), 7.89 (d, J=8.1Hz, 2H).
References
[1] Patent: WO2013/78430, 2013, A1. Location in patent: Paragraph 0353
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 23, p. 10101 - 10111
[3] Patent: US9353075, 2016, B2. Location in patent: Page/Page column 122
[4] Patent: WO2009/71504, 2009, A1. Location in patent: Page/Page column 65
[5] Patent: WO2010/15653, 2010, A1. Location in patent: Page/Page column 39
(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58