α-MSH (11-13) (free acid)

Product Name: α-MSH (11-13) (free acid)
CAS No.: 67727-97-3
Chemical Name: α-MSH (11-13) (free acid)
Synonyms: KPV;msh(11-13;ACTH-(11-13);H-Lys-Pro-Val-OH;ALPHA-MSH (11-13);α-MSH(11-13)[pig];α-MSH(11-13)[human];H-LYS-PRO-VAL-OH ACOH;α-Melanotropin(11-13);alpha-MSH(11-13) acetate
CBNumber: CB1241534
Molecular Formula: C16H30N4O4
Formula Weight: 342.43
MOL File: 67727-97-3.mol

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α-MSH (11-13) (free acid) Property

storage temp.: -15°C
InChI: InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
InChIKey: YSPZCHGIWAQVKQ-AVGNSLFASA-N
SMILES: C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PRO0001392
Product name: ALPHA-MSH (11-13) ACETATE SALT
Purity: 95.00%
Packaging: 5MG
Price: $504.86
Updated: 2021/12/16

AHH

Product number: MT-19210
Product name: alpha-Msh(11-13)(freeacid)acetatesalt
Purity: 98%
Packaging: 0.25g
Price: $898
Updated: 2021/12/16

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α-MSH (11-13) (free acid) Chemical Properties,Usage,Production

Description

α-MSH (11-13) (free acid) is a synthetic, nonsteroidal compound that binds to and activates α-melanocyte-stimulating hormone receptors. It has been used as an antiinflammatory agent in the treatment of inflammatory bowel disease and bowel disease. It is also being studied as a contraceptive and an elastase inhibitor. This drug has shown some promise in the treatment of autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, and type 1 diabetes mellitus. It is thought that α-MSH (11-13) (free acid) acetate salt may inhibit the production of inflammatory cells by inhibiting leukocyte elastase activity.

Definition

ChEBI: Lys-Pro-Val is an oligopeptide.

Biological Activity

The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.

References

[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.

α-MSH (11-13) (free acid) Preparation Products And Raw materials

Raw materials

Preparation Products

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α-MSH (11-13) (free acid) Suppliers

China 70 The Netherlands 1 United Kingdom 1 United States 5 Global 77

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4847
Advantage: 58

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Chengdu Yontinotech Co.,Ltd

Tel: 028-86293627 15228898511
Fax: 028-86293627
Email: sales@yontinotech.com
Country: China
ProdList: 110
Advantage: 56

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-025-58361106-805-805 13082558573
Fax: 025-58361106-806
Email: liugang@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6756
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Alfa Chemistry

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Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
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BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
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Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

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View Lastest Price from α-MSH (11-13) (free acid) manufacturers

Shanghai Affida new material science and technology center

Product: KPV 67727-97-3
Price: US $0.00-0.00/BOX
Min. Order: 1BOX
Purity: 99
Supply Ability: 50000KG/month
Release date: 2024-06-17

Shandong Huizhihan Supply Chain Co., Ltd

Product: kpv 67727-97-3
Price: US $0.00-0.00/BOX
Min. Order: 1BOX
Purity: 99.99%
Supply Ability: 1000
Release date: 2024-10-31

Hangzhou Hyper Chemicals Limited

Product: KPV 67727-97-3
Price: US $0.00-0.00/Gram
Min. Order: 10Gram
Purity: HPLC 98%
Supply Ability: 20KG
Release date: 2024-08-08

67727-97-3, α-MSH (11-13) (free acid)Related Search:

α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) ALPHA-MSH (11-13) ALPHA-MSH ALPHA-MSH ACTH (1-13) α-MSH (11-13) (free acid)

α-Melanotropin(11-13)

α-Melanotropin(11-13)[human]

α-Melanotropin(11-13)[pig]

α-MSH(11-13)[human]

α-MSH(11-13)[pig]

a-MSH (11-13) (free acid)

H-LYS-PRO-VAL-OH ACETATE SALT

H-LYS-PRO-VAL-OH ACOH

ALPHA-MSH (11-13)

ALPHA-MSH (11-13) ACETATE SALT

msh(11-13

.alpha.-MSH (11-13) (free acid)

H-Lys-Pro-Val-OH

alpha-Msh (11-13) (free acid) acetate salt

L-Valine, L-lysyl-L-prolyl-

α-MSH (11-13) (free acid)

ACTH-(11-13)

(2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid

alpha-MSH(11-13) acetate

KPV

KPV (α-MSH (11-13) (free acid)

KPV,ALPHA-MSH (11-13) ACETATE SALT

α-MSH (11-13) (free acid) acetate salt

KPV Peptide (ACTH 11-13)

67727-97-3

C16H30N4O4C2H4O2