α-MSH (11-13) (free acid)
- Product Name
- α-MSH (11-13) (free acid)
- CAS No.
- 67727-97-3
- Chemical Name
- α-MSH (11-13) (free acid)
- Synonyms
- KPV;msh(11-13;ACTH-(11-13);H-Lys-Pro-Val-OH;ALPHA-MSH (11-13);α-MSH(11-13)[pig];α-MSH(11-13)[human];H-LYS-PRO-VAL-OH ACOH;α-Melanotropin(11-13);alpha-MSH(11-13) acetate
- CBNumber
- CB1241534
- Molecular Formula
- C16H30N4O4
- Formula Weight
- 342.43
- MOL File
- 67727-97-3.mol
α-MSH (11-13) (free acid) Property
- storage temp.
- -15°C
- InChI
- InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
- InChIKey
- YSPZCHGIWAQVKQ-AVGNSLFASA-N
- SMILES
- C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
N-Bromosuccinimide Price
- Product number
- PRO0001392
- Product name
- ALPHA-MSH (11-13) ACETATE SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.86
- Updated
- 2021/12/16
- Product number
- MT-19210
- Product name
- alpha-Msh(11-13)(freeacid)acetatesalt
- Purity
- 98%
- Packaging
- 0.25g
- Price
- $898
- Updated
- 2021/12/16
α-MSH (11-13) (free acid) Chemical Properties,Usage,Production
Description
α-MSH (11-13) (free acid) is a synthetic, nonsteroidal compound that binds to and activates α-melanocyte-stimulating hormone receptors. It has been used as an antiinflammatory agent in the treatment of inflammatory bowel disease and bowel disease. It is also being studied as a contraceptive and an elastase inhibitor. This drug has shown some promise in the treatment of autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, and type 1 diabetes mellitus. It is thought that α-MSH (11-13) (free acid) acetate salt may inhibit the production of inflammatory cells by inhibiting leukocyte elastase activity.
Definition
ChEBI: Lys-Pro-Val is an oligopeptide.
Biological Activity
The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
References
[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.
α-MSH (11-13) (free acid) Preparation Products And Raw materials
Raw materials
Preparation Products
α-MSH (11-13) (free acid) Suppliers
- Tel
- +86-17380623303 +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4812
- Advantage
- 58
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 028-86293627 15228898511
- Fax
- 028-86293627
- sales@yontinotech.com
- Country
- China
- ProdList
- 110
- Advantage
- 56
- Tel
- 17705183659
- Fax
- 84523390
- sales@njleonbiotech.com
- Country
- China
- ProdList
- 5501
- Advantage
- 55
- Tel
- 025-025-58361106-805-805 13082558573
- Fax
- 025-58361106-806
- liugang@njpeptide.com
- Country
- China
- ProdList
- 9980
- Advantage
- 55
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 6968
- Advantage
- 58
- Tel
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
- ProdList
- 24072
- Advantage
- 58
- Tel
- 16314854226; +16314854226
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19741
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
View Lastest Price from α-MSH (11-13) (free acid) manufacturers
- Product
- kpv 67727-97-3
- Price
- US $0.00-0.00/BOX
- Min. Order
- 1BOX
- Purity
- 99.99%
- Supply Ability
- 1000
- Release date
- 2024-10-31
- Product
- KPV 67727-97-3
- Price
- US $0.00-0.00/BOX
- Min. Order
- 1BOX
- Purity
- 99
- Supply Ability
- 50000KG/month
- Release date
- 2024-06-17
- Product
- KPV 67727-97-3
- Price
- US $80.00-75.00/Box
- Min. Order
- 1Box
- Purity
- 99%
- Supply Ability
- 66666
- Release date
- 2023-12-18