ChemicalBook > CAS DataBase List > α-MSH (11-13) (free acid)
α-MSH (11-13) (free acid)
- Product Name
- α-MSH (11-13) (free acid)
- CAS No.
- 67727-97-3
- Chemical Name
- α-MSH (11-13) (free acid)
- Synonyms
- KPV;msh(11-13;Lys-pro-val;ACTH-(11-13);H-Lys-Pro-Val-OH;ALPHA-MSH (11-13);α-MSH(11-13)[pig];KPV best quotation;α-MSH(11-13)[human];H-LYS-PRO-VAL-OH ACOH
- CBNumber
- CB1241534
- Molecular Formula
- C16H30N4O4
- Formula Weight
- 342.43
- MOL File
- 67727-97-3.mol
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α-MSH (11-13) (free acid) Property
- storage temp.
- -15°C
- InChI
- InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
- InChIKey
- YSPZCHGIWAQVKQ-AVGNSLFASA-N
- SMILES
- C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- PRO0001392
- Product name
- ALPHA-MSH (11-13) ACETATE SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.86
- Updated
- 2021/12/16
AHH
- Product number
- MT-19210
- Product name
- alpha-Msh(11-13)(freeacid)acetatesalt
- Purity
- 98%
- Packaging
- 0.25g
- Price
- $898
- Updated
- 2021/12/16
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α-MSH (11-13) (free acid) Chemical Properties,Usage,Production
Description
α-MSH (11-13) (free acid) is a synthetic, nonsteroidal compound that binds to and activates α-melanocyte-stimulating hormone receptors. It has been used as an antiinflammatory agent in the treatment of inflammatory bowel disease and bowel disease. It is also being studied as a contraceptive and an elastase inhibitor. This drug has shown some promise in the treatment of autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, and type 1 diabetes mellitus. It is thought that α-MSH (11-13) (free acid) acetate salt may inhibit the production of inflammatory cells by inhibiting leukocyte elastase activity.
Uses
α-MSH(11-13) (ACTH-(11-13)) is the 11-13 amino acid (lysine-proline-valine) sequence of α-MSH (HY-P0252), which reduces fever in rabbits[1].
Definition
ChEBI: Lys-Pro-Val is an oligopeptide.
Biological Activity
The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
References
[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.
α-MSH (11-13) (free acid) Preparation Products And Raw materials
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View Lastest Price from α-MSH (11-13) (free acid) manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- α-MSH (11-13) (free acid) 67727-97-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-21
Ningbo Qingteng Plastic Cost.,Ltd.
- Product
- KPV best quotation 67727-97-3
- Price
- US $10.00-7.00/VIAL
- Min. Order
- 10VIAL
- Purity
- 99.9
- Supply Ability
- 20000
- Release date
- 2025-11-21
Shanghai Yimeixin Technology Co., LTD
- Product
- KPV 67727-97-3
- Price
- US $0.00/box
- Min. Order
- 1box
- Purity
- 0.99
- Supply Ability
- 10tons
- Release date
- 2025-09-26
67727-97-3, α-MSH (11-13) (free acid)Related Search:
α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
ALPHA-MSH (11-13)
ALPHA-MSH
ALPHA-MSH
ACTH (1-13)
α-MSH (11-13) (free acid)