2,4-DIFLUOROCINNAMIC ACID
- Product Name
- 2,4-DIFLUOROCINNAMIC ACID
- CAS No.
- 94977-52-3
- Chemical Name
- 2,4-DIFLUOROCINNAMIC ACID
- Synonyms
- RARECHEM BK HW 0121;2,4-DifluorocinnamicAci;2,4-DIFLUOROCINNAMIC ACID;2,4-DIFLUOROCINNAMADEHYDE;trans-2,4-Difluorocinnamic;2,4-DifluorocinnamicAcid>trans-2,4-Difluorociamic acid;(E)-2,4-Difluorocinnamic Acid;RANS-2,4-DIFLUOROCINNAMIC ACID;TRANS-2,4-DIFLUOROCINNAMIC ACID
- CBNumber
- CB1243114
- Molecular Formula
- C9H6F2O2
- Formula Weight
- 184.14
- MOL File
- 94977-52-3.mol
2,4-DIFLUOROCINNAMIC ACID Property
- Melting point:
- 216-218 °C (lit.)
- Boiling point:
- 272.0±25.0 °C(Predicted)
- Density
- 1.3056 (estimate)
- storage temp.
- Storage temp. 2-8°C
- pka
- 4.29±0.13(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- CAS DataBase Reference
- 94977-52-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-26/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 290335
- Product name
- trans-2,4-Difluorocinnamic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $149
- Updated
- 2023/06/20
- Product number
- D2343
- Product name
- 2,4-Difluorocinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $79
- Updated
- 2023/06/20
- Product number
- D447613
- Product name
- 2,4-Difluorocinnamic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD76238
- Product name
- trans-2,4-Difluorocinnamic acid
- Packaging
- 10g
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CS-W017017
- Product name
- (E)-3-(2,4-Difluorophenyl)acrylicacid
- Packaging
- 100g
- Price
- $313
- Updated
- 2021/12/16
2,4-DIFLUOROCINNAMIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow powder
Uses
trans-2,4-Difluorocinnamic acid may be used in chemical synthesis.
Synthesis
4519-40-8
5329-14-6
79-10-7
94977-52-3
Example 5: Synthesis of (E)-3-(2,4-difluorophenyl)acrylic acid 1. 77.5 g of 2,3-difluoroaniline was slowly added dropwise to a mixture consisting of 124 mL of concentrated hydrochloric acid, sulfuric acid and 472 mL of water at 0 °C. 2. maintaining the reaction temperature at 0 °C, a solution of 48.3 g of sodium nitrite dissolved in 90 mL of water was slowly added dropwise. 3. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 30 minutes. 4. sulfamic acid was added to quench the excess nitrite. 5. In a separate vessel, 0.34 g of palladium(II) acetate was added to 54.8 g of acrylic acid and the mixture was heated to 47°C. 6. the diazonium salt solution prepared in step 4 was slowly added dropwise over a period of 2 hours at 47 °C, controlling the reaction temperature to not exceed 49 °C. the reaction was carried out at the same time. 7. after completion of the dropwise addition, the reaction mixture was continued to be stirred at the same temperature for 2 hours. 8. After completion of the reaction, the mixture was cooled to room temperature and the solid product was collected by filtration. 9. The solid product was washed with water and dried. 10. 10. 105.1 g of (E)-3-(2,4-difluorophenyl)acrylic acid was obtained in 95% yield of the theoretical value, with a melting point of 204-205 °C. The reaction was carried out at the same temperature.
References
[1] Patent: US2002/115885, 2002, A1
2,4-DIFLUOROCINNAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DIFLUOROCINNAMIC ACID Suppliers
- Tel
- --
- Fax
- --
- brunschwig@brunschwig.nl
- Country
- The Netherlands
- ProdList
- 4996
- Advantage
- 67
View Lastest Price from 2,4-DIFLUOROCINNAMIC ACID manufacturers
- Product
- 2,4-DIFLUOROCINNAMIC ACID 94977-52-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-09
- Product
- 2,4-DIFLUOROCINNAMIC ACID 94977-52-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-01
- Product
- 2,4-DIFLUOROCINNAMIC ACID 94977-52-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11