2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID

Product Name: 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID
CAS No.: 37102-48-0
Chemical Name: 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID
Synonyms: 2-Methyl-3-pyrrolecarboxylic acid;2-Methylpyrrole-3-carboxylic acid;2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID;1H-Pyrrole-3-carboxylic acid, 2-Methyl-;2-Methyl-1H-Pyrrole-3-Carboxylic Acid(WX614100)
CBNumber: CB12446698
Molecular Formula: C6H7NO2
Formula Weight: 125.13
MOL File: 37102-48-0.mol

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2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID Property

Melting point:: 178-179℃
Boiling point:: 322.4±22.0 °C(Predicted)
Density: 1.295
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 5.60±0.50(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C6H7NO2/c1-4-5(6(8)9)2-3-7-4/h2-3,7H,1H3,(H,8,9)
InChIKey: YBJBJOLFTYIFKP-UHFFFAOYSA-N
SMILES: N1C=CC(C(O)=O)=C1C

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR01791
Product name: 2-Methyl-1H-pyrrole-3-carboxylic acid
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: M308600
Product name: 2-Methyl-1H-pyrrole-3-carboxylic acid
Packaging: 500mg
Price: $130
Updated: 2021/12/16

TRC

Product number: M308600
Product name: 2-Methyl-1H-pyrrole-3-carboxylic acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 283753
Product name: 2-Methyl-1H-pyrrole-3-carboxylic acid
Packaging: 100mg
Price: $382
Updated: 2021/12/16

Matrix Scientific

Product number: 077448
Product name: 2-Methyl-1H-pyrrole-3-carboxylic acid
Packaging: 1g
Price: $420
Updated: 2021/12/16

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2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

2-Methyl-1H-Pyrrole-3-carboxylic acid was examined for its inhibitory properties of BET bromodomains. 2-Methyl-1H-Pyrrole-3-carboxylic acid is also patented as a plant-growth regulator.

Synthesis

936-12-9

37102-48-0

Example 149a Synthesis of 2-methyl-1H-pyrrole-3-carboxylic acid: an aqueous solution (20 mL) of lithium hydroxide (1.563 g, 65.3 mmol) was added to a solution of dioxane (20 mL) containing ethyl 2-methyl-1H-pyrrole-3-carboxylate (2.0 g, 13.06 mmol). The reaction mixture was heated under reflux conditions for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted by partitioning with ethyl acetate and 1 M hydrochloric acid. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target compound 2-methyl-1H-pyrrole-3-carboxylic acid (1.513 g, 93% yield).

References

[1] Patent: US2014/275079, 2014, A1. Location in patent: Paragraph 0604
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 29, p. 7911 - 7914
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 10, p. 2225 - 2233
[4] Chemische Berichte, 1911, vol. 44, p. 490
[5] Chemische Berichte, 1918, vol. 51, p. 569

2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID Suppliers

China 52 Germany 1 India 1 Ukraine 2 United Kingdom 1 United States 8 Global 65

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37102-48-0, 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACIDRelated Search:

3-CARBOXY-1,4-DIMETHYL-1H-PYRROLE-2-ACETIC ACID 2-CARBOXYMETHYL-1-METHYLPYRROLE-3-CARBOXYLIC ACID 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate Ethyl2,5-dimethylpyrrole-3-carboxylate 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID 2-ETHYL ESTER 4-BENZYL 2-ETHYL 3-(2-ETHOXY-2-OXOETHYL)-5-METHYL-1H-PYRROLE-2,4-DICARBOXYLATE DIMETHYL INDOLE-2,3-DICARBOXYLATE 2,5-DIMETHYL-1-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID 5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE 2-BENZYL 4-ETHYL 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLATE ETHYL-1-BENZYL-2,4-DIMETHYLPYRROLE-3-CARBOXYLATE ZERENEX E/5030028 5-BROMOMETHYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER ETHYL 4,5-DIPHENYL-2-METHYL-3-PYRROLECARBOXYLATE

2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID

2-Methylpyrrole-3-carboxylic acid

1H-Pyrrole-3-carboxylic acid, 2-Methyl-

2-Methyl-1H-Pyrrole-3-Carboxylic Acid(WX614100)

2-Methyl-3-pyrrolecarboxylic acid

37102-48-0