ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE

Product Name: ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
CAS No.: 13720-94-0
Chemical Name: ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
Synonyms: NSC 136916;NSC 109461;AURORA 18125;4-CHLORO-3-QUINOLINECARBOXYLATE;ETHYL 4-CHLOROQUINOLINE-3-CARBOXYLATE;ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE;4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester;4-chloro-3-Quinolinecarboxylic acid ethyl ester (6CI 8CI 9CI ACI);3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester (6CI, 8CI, 9CI, ACI)
CBNumber: CB1245057
Molecular Formula: C12H10ClNO2
Formula Weight: 235.67
MOL File: 13720-94-0.mol

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ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Property

Melting point:: 46-48°C
Boiling point:: 128-129 °C(Press: 0.2 Torr)
Density: 1.286
storage temp.: Storage temp. -20°C
pka: 1.78±0.24(Predicted)
form: powder to crystal
color: White to Orange to Green
InChIKey: DWXQUAHMZWZXHP-UHFFFAOYSA-N
CAS DataBase Reference: 13720-94-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0194
Product name: Ethyl 4-chloroquinoline-3-carboxylate
Purity: Aldrich
Packaging: 1g
Price: $286
Updated: 2025/07/31

TCI Chemical

Product number: E1201
Product name: Ethyl 4-Chloroquinoline-3-carboxylate
Packaging: 200MG
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: E1201
Product name: Ethyl 4-Chloroquinoline-3-carboxylate
Packaging: 1G
Price: $188
Updated: 2024/03/01

TRC

Product number: E903695
Product name: Ethyl 4-Chloroquinoline-3-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC147914
Product name: 4-Chloro-quinoline-3-carboxylic acid methylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 4-chloroquinoline-3-carboxylate is used as organic chemical synthesis intermediate.

Synthesis

26892-90-0

13720-94-0

Synthesis of ethyl 4-chloroquinoline-3-carboxylate (A2): ethyl 4-hydroxyquinoline-3-carboxylate (A1) (1.5 g, 7 mmol) solid was placed in a reaction vial and phosphorus oxychloride (POCl3) (2.2 g, 1.3 mL, 14 mmol) was added. The reaction mixture was heated at 110 °C for 20 min. Upon completion of the reaction, the mixture was slowly poured into a pre-cooled mixture of aqueous ammonia solution (28-30%) and ice and stirred until a granular solid was formed. The reaction mixture was extracted with ether (3 x 40 mL), the organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give an oily product. After standing, the product crystallized (1.44 g, 6 mmol, 87% yield) and could be used for subsequent reactions without further purification.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 21, p. 6351 - 6363
[2] Patent: WO2005/123686, 2005, A1. Location in patent: Page/Page column 75-76
[3] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[4] Patent: CN108623589, 2018, A. Location in patent: Paragraph 0142; 0149
[5] Patent: CN108623581, 2018, A. Location in patent: Page/Page column 7

ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Suppliers

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View Lastest Price from ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE 13720-94-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE 13720-94-0
Price: US $0.01/KG
Min. Order: 500g
Purity: 98%; 99%
Supply Ability: 500g；1kg； 10kg; 25kg
Release date: 2020-01-08

13720-94-0, ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATERelated Search:

ETHYL 4-CHLORO-6-FLUOROQUINOLINE-3-CARBOXYLATE 4,6-DICHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER ETHYL 4-CHLORO-6-METHYLQUINOLINE-3-CARBOXYLATE ETHYL 4-CHLORO-6,8-DIMETHYLQUINOLINE-3-CARBOXYLATE ETHYL 4-CHLORO-5,7-DIMETHYLQUINOLINE-3-CARBOXYLATE ETHYL 4,6-DICHLORO-3-QUINOLINECARBOXYLATE ETHYL 4-CHLORO-5,8-DIMETHYLQUINOLINE-3-CARBOXYLATE ETHYL 4-CHLORO-6,8-DIFLUOROQUINOLINE-3-CARBOXYLATE ETHYL 4-CHLORO-8-FLUOROQUINOLINE-3-CARBOXYLATE 4-CHLORO-5,8-DIFLUOROQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE 4-CHLORO-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER 4,7-DICHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER ETHYL 8-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE ETHYL 4,8-DICHLORO-3-QUINOLINECARBOXYLATE ETHYL 4,7,8-TRICHLORO-3-QUINOLINECARBOXYLATE ETHYL 4,5,8-TRICHLORO-3-QUINOLINECARBOXYLATE

AURORA 18125

ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE

ETHYL 4-CHLOROQUINOLINE-3-CARBOXYLATE

4-CHLORO-3-QUINOLINECARBOXYLATE

4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

NSC 109461

NSC 136916

3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester

3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester (6CI, 8CI, 9CI, ACI)

4-chloro-3-Quinolinecarboxylic acid ethyl ester (6CI 8CI 9CI ACI)

13720-94-0

ESTER

Acids and Derivatives

Heterocycles