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FRESELESTAT

Product Name
FRESELESTAT
CAS No.
208848-19-5
Chemical Name
FRESELESTAT
Synonyms
ONO6818;ONO 6818;ONO-6818;Freselesat;ONO-PO-736;FRESELESTAT;Freselestat (ONO-6818);5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide;1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-
CBNumber
CB12451308
Molecular Formula
C23H28N6O4
Formula Weight
452.51
MOL File
208848-19-5.mol
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FRESELESTAT Property

Melting point:
151-153oC
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
12.43±0.46(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5651
Product name
ONO6818
Purity
≥98%(HPLC)
Packaging
10
Price
$252
Updated
2021/12/16
TRC
Product number
F764500
Product name
Freselestat
Packaging
2.5mg
Price
$120
Updated
2021/12/16
TRC
Product number
F764500
Product name
Freselestat
Packaging
25mg
Price
$990
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008113
Product name
ONO-6818
Purity
95.00%
Packaging
1G
Price
$918.23
Updated
2021/12/16
ChemScene
Product number
CS-0007925
Product name
Freselestat
Packaging
10mg
Price
$600
Updated
2021/12/16
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FRESELESTAT Chemical Properties,Usage,Production

Uses

Freselestat is a highly potent nonpeptidic orally active inhibitor of human neutrophil elastase (HNE) and can be used as treatment for neutrophil-predominant inflammatory lung diseases.

in vivo

Freselestat (ONO-6818; 10-100 mg/kg; oral administration; daily; for 8 weeks) treatment attenuates dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. ONO-6818 inhibits acute lung injury induced by HNE by minimizing lung hemorrhage and accumulation of neutrophils in the lung[1].

Animal Model:Male Wistar rats (228 g) induced by human neutrophil elastase (HNE)[1]
Dosage:10 mg/kg, 100 mg/kg
Administration:Oral administration; daily; for 8 weeks
Result:Attenuated dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid.

storage

Store at -20°C

FRESELESTAT Preparation Products And Raw materials

Raw materials

Preparation Products

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FRESELESTAT Suppliers

China 19 India 1 United Kingdom 1 United States 9 Global 30
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

208848-19-5, FRESELESTATRelated Search:

FRESELESTAT

  • FRESELESTAT
  • 1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-
  • ONO 6818
  • ONO6818
  • ONO-6818
  • ONO-PO-736
  • 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
  • Freselesat
  • Freselestat (ONO-6818)
  • 208848-19-5
  • C23H28N6O4