ChemicalBook > CAS DataBase List > FRESELESTAT
FRESELESTAT
- Product Name
- FRESELESTAT
- CAS No.
- 208848-19-5
- Chemical Name
- FRESELESTAT
- Synonyms
- ONO6818;ONO 6818;ONO-6818;Freselesat;ONO-PO-736;FRESELESTAT;Freselestat (ONO-6818);5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide;1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-
- CBNumber
- CB12451308
- Molecular Formula
- C23H28N6O4
- Formula Weight
- 452.51
- MOL File
- 208848-19-5.mol
More
Less
FRESELESTAT Property
- Melting point:
- 151-153oC
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 12.43±0.46(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
More
Less
N-Bromosuccinimide Price
Tocris
- Product number
- 5651
- Product name
- ONO6818
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $252
- Updated
- 2021/12/16
TRC
- Product number
- F764500
- Product name
- Freselestat
- Packaging
- 2.5mg
- Price
- $120
- Updated
- 2021/12/16
TRC
- Product number
- F764500
- Product name
- Freselestat
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0008113
- Product name
- ONO-6818
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $918.23
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0007925
- Product name
- Freselestat
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
More
Less
FRESELESTAT Chemical Properties,Usage,Production
Uses
Freselestat is a highly potent nonpeptidic orally active inhibitor of human neutrophil elastase (HNE) and can be used as treatment for neutrophil-predominant inflammatory lung diseases.
in vivo
Freselestat (ONO-6818; 10-100 mg/kg; oral administration; daily; for 8 weeks) treatment attenuates dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. ONO-6818 inhibits acute lung injury induced by HNE by minimizing lung hemorrhage and accumulation of neutrophils in the lung[1].
| Animal Model: | Male Wistar rats (228 g) induced by human neutrophil elastase (HNE)[1] |
| Dosage: | 10 mg/kg, 100 mg/kg |
| Administration: | Oral administration; daily; for 8 weeks |
| Result: | Attenuated dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. |
storage
Store at -20°C
FRESELESTAT Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
FRESELESTAT Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@acccorporation.com
- Country
- United States
- ProdList
- 6820
- Advantage
- 51