2-BROMO-6-(CHLOROMETHYL)PYRIDINE
- Product Name
- 2-BROMO-6-(CHLOROMETHYL)PYRIDINE
- CAS No.
- 727356-19-6
- Chemical Name
- 2-BROMO-6-(CHLOROMETHYL)PYRIDINE
- Synonyms
- 2-BROMO-6-(CHLOROMETHYL)PYRIDINE;Pyridine, 2-bromo-6-(chloromethyl)-
- CBNumber
- CB12454455
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 727356-19-6.mol
2-BROMO-6-(CHLOROMETHYL)PYRIDINE Property
- Boiling point:
- 262.5±25.0 °C(Predicted)
- Density
- 1.631±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.73±0.12(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5484AJ
- Product name
- 2-Bromo-6-(chloromethyl)pyridine
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 118800
- Product name
- 2-Bromo-6-(chloromethyl)pyridine
- Purity
- >97%
- Packaging
- 500mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- OR311109
- Product name
- 2-Bromo-6-(chloromethyl)pyridine
- Packaging
- 500mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 3H32-D-3B
- Product name
- 2-Bromo-6-(chloromethyl)pyridine
- Packaging
- 500mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- 118800
- Product name
- 2-Bromo-6-(chloromethyl)pyridine
- Purity
- >97%
- Packaging
- 1g
- Price
- $279
- Updated
- 2021/12/16
2-BROMO-6-(CHLOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
Synthesis
33674-96-3
727356-19-6
Step 1: Preparation of 2-bromo-6-(chloromethyl)pyridine 6-Bromopyridine-2-methanol (5.00 g, 25.5 mmol) was dissolved in chloroform (30 ml), thionyl chloride (2.8 ml, 38.3 mmol) was added slowly and the reaction was stirred for 3 hours at room temperature. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue was neutralized by adding saturated aqueous sodium bicarbonate solution, and the precipitate was collected by filtration. After washing the precipitate with water, it was dried under vacuum to obtain white solid 2-bromo-6-(chloromethyl)pyridine (5.20 g, 99% yield).
References
[1] Patent: US2006/205731, 2006, A1. Location in patent: Page/Page column 52
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 23, p. 8421 - 8439
[3] Patent: WO2009/120789, 2009, A1. Location in patent: Page/Page column 80; 81
[4] Patent: WO2007/88999, 2007, A1. Location in patent: Page/Page column 115-116
[5] Patent: WO2008/73461, 2008, A2. Location in patent: Page/Page column 132; 133
2-BROMO-6-(CHLOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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