3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
- Product Name
- 3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
- CAS No.
- 1010814-94-4
- Chemical Name
- 3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
- Synonyms
- tert-Butyl 3-(2-(tert-butoxy);tert-Butyl 2-(1-Boc-4-oxopiperidin-3-yl)acetate;3-(2-tert-butoxy-2-oxoethyl)-4-oxopiperidine-1-carboxylate;tert-butyl 3-(2-tert-butoxy-2-oxoethyl)-4-oxopiperidine-1-carboxylate;tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate 97%;1,1-Dimethylethyl 1-[(1,1-dimethylethoxy)carbonyl]-4-oxo-3-piperidineacetate;tert-butyl 3-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-4-oxopiperidine-1-carboxylate;3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
- CBNumber
- CB12456303
- Molecular Formula
- C16H27NO5
- Formula Weight
- 313.39
- MOL File
- 1010814-94-4.mol
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Property
- Boiling point:
- 396.6±27.0 °C(Predicted)
- Density
- 1.086±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.05±0.40(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B701905
- Product name
- tert-Butyl3-(2-(tert-Butoxy)-2-oxoethyl)-4-oxopiperidine-1-Carboxylate
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- OR315309
- Product name
- tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 4H56-1-310
- Product name
- tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- OR315309
- Product name
- tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $256
- Updated
- 2021/12/16
- Product number
- 4H56-1-310
- Product name
- tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $303
- Updated
- 2021/12/16
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production
Synthesis
5292-43-3
1010814-94-4
To a tetrahydrofuran (THF, 300 mL) solution of diisopropylamine (13.5 mL, 96 mmol) was slowly added n-butyllithium (n-BuLi, 2.5 M in hexane, 32 mL) dropwise at -78 °C. The reaction mixture was slowly warmed to -10 °C and then cooled to -78 °C again. Subsequently, a solution of tert-butyl 4-oxopiperidine-1-carboxylate (10 g, 50 mmol) in THF (50 mL) was added dropwise and stirring was continued for 15 min at -78 °C. Next, a mixed solution of tert-butyl bromoacetate (12.6 mL, 85 mmol) with HMPT (5 mL) in THF (30 mL) was added dropwise, and the reaction mixture was stirred at -78 °C for 4 h before slowly warming up to room temperature. The reaction mixture was quenched with saturated aqueous ammonium chloride (NH4Cl) and extracted with ethyl acetate (EA). After post-treatment and purification by column chromatography (eluent: n-hexane/ethyl acetate=4:1), the target product tert-butyl 3-(2-tert-butoxy-2-oxoethyl)-4-oxopiperidine-1-carboxylate was obtained as 7.6 g (50.6% yield, yellow oil).1H NMR (CDCl3) δ: 4.40-4.20 (m, 2H); 3.25-3.15 (m, 1H). 1H); 3.00-2.80 (m, 2H); 2.70-2.40 (m, 3H); 2.30-2.10 (m, 1H); 1.51 (s, 9H), 1.46 (s, 9H).
References
[1] Patent: WO2008/26172, 2008, A1. Location in patent: Page/Page column 63
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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