1-BOC-3-ETHYL-PIPERIDIN-4-ONE
- Product Name
- 1-BOC-3-ETHYL-PIPERIDIN-4-ONE
- CAS No.
- 117565-57-8
- Chemical Name
- 1-BOC-3-ETHYL-PIPERIDIN-4-ONE
- Synonyms
- 1-Boc-3-ethyl-4-piperidinone;1-BOC-3-ETHYL-PIPERIDIN-4-ONE;3-ethyl-4-oxopiperidine-1-carboxylate;tert-butyl3-ethyl-4-oxopiperidine -1-carboxylate;1-Piperidinecarboxylic acid, 3-ethyl-4-oxo-, 1,1-dimethylethyl ester
- CBNumber
- CB5841970
- Molecular Formula
- C12H21NO3
- Formula Weight
- 227.3
- MOL File
- 117565-57-8.mol
1-BOC-3-ETHYL-PIPERIDIN-4-ONE Property
- Boiling point:
- 315.4±35.0 °C(Predicted)
- Density
- 1.039±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.54±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B701040
- Product name
- tert-Butyl3-Ethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB142875
- Product name
- tert-Butyl 3-ethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 2g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- FB142875
- Product name
- tert-Butyl 3-ethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- FB142875
- Product name
- tert-Butyl 3-ethyl-4-oxopiperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CHM0094713
- Product name
- 1-BOC-3-ETHYL-PIPERIDIN-4-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.72
- Updated
- 2021/12/16
1-BOC-3-ETHYL-PIPERIDIN-4-ONE Chemical Properties,Usage,Production
Uses
tert-Butyl 3-Ethyl-4-oxopiperidine-1-carboxylate is used as a reactant in the preparation of 3-(piperidinosulfonyl)benzamides useful in mono- and combination treatment of HBV infection.
Synthesis
104777-74-4
24424-99-5
117565-57-8
The general procedure for the synthesis of tert-butyl 3-ethyl-4-oxopiperidine-1-carboxylate from 3-ethylpiperidin-4-one and di-tert-butyl dicarbonate was carried out as follows: the reaction was carried out by suspending 3-ethylpiperidin-4-one (2.90 g, 10.2 mmol) in 6N hydrochloric acid (85 ml) at reflux for 16 hours. Upon completion of the reaction, the reaction solution was concentrated and residual water was removed by azeotroping three times with isopropanol to give a yellow solid. The solid was dissolved in a 1:1 solvent mixture of dichloromethane and methanol (50 ml) and triethylamine (3.08 g, 4.3 ml, 30.5 mmol) and di-tert-butyl dicarbonate (3.32 g, 15.2 mmol) were added sequentially. The reaction mixture was stirred at 23 °C for 16 h. The reaction solution was subsequently concentrated. To the concentrate was added 0.5N sodium hydroxide solution (50 ml) and extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, purification by silica gel column chromatography (eluent: 10% ethyl acetate-hexane) gave 1.92 g (8.46 mmol, 83% yield) of the target product tert-butyl 3-ethyl-4-oxopiperidine-1-carboxylate as a colorless oil. Mass spectrum (ESI+): m/z 228 [M+1]+.
References
[1] Patent: US2005/182095, 2005, A1. Location in patent: Page/Page column 30
1-BOC-3-ETHYL-PIPERIDIN-4-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BOC-3-ETHYL-PIPERIDIN-4-ONE manufacturers
- Product
- 1-BOC-3-ETHYL-PIPERIDIN-4-ONE 117565-57-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13