1-BOC-3-BENZYL-PIPERIDIN-4-ONE
- Product Name
- 1-BOC-3-BENZYL-PIPERIDIN-4-ONE
- CAS No.
- 193274-82-7
- Chemical Name
- 1-BOC-3-BENZYL-PIPERIDIN-4-ONE
- Synonyms
- 1-Boc-3-benzyl-4-piperidone;1-BOC-3-BENZYL-PIPERIDIN-4-ONE;3-benzyl-4-oxopiperidine-1-carboxylate;tert-Butyl 3-benzyl-4-oxopiperidine-1-carboxylate;1-Piperidinecarboxylicacid, 4-oxo-3-(phenylmethyl)-, 1,1-dimethylethyl ester;TERT-BUTYL 3-BENZYL-4-OXOPIPERIDINE-1-CARBOXYLATE1-BOC-3-BENZYL-PIPERIDIN-4-ONE
- CBNumber
- CB6842565
- Molecular Formula
- C17H23NO3
- Formula Weight
- 289.37
- MOL File
- 193274-82-7.mol
1-BOC-3-BENZYL-PIPERIDIN-4-ONE Property
- Boiling point:
- 409.0±38.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.58±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0094712
- Product name
- 1-BOC-3-BENZYL-PIPERIDIN-4-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.85
- Updated
- 2021/12/16
- Product number
- 193274827
- Product name
- tert-Butyl3-benzyl-4-oxopiperidine-1-carboxylate
- Packaging
- 5g
- Price
- $499.5
- Updated
- 2021/12/16
- Product number
- SC-35200
- Product name
- 1-Boc-3-benzyl-piperidin-4-one
- Purity
- 95
- Packaging
- 5g
- Price
- $523
- Updated
- 2021/12/16
- Product number
- CM179100
- Product name
- tert-butyl3-benzyl-4-oxopiperidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $701
- Updated
- 2021/12/16
- Product number
- CD11175252
- Product name
- tert-Butyl3-benzyl-4-oxopiperidine-1-carboxylate
- Purity
- 98%
- Packaging
- 10g
- Price
- $743
- Updated
- 2021/12/16
1-BOC-3-BENZYL-PIPERIDIN-4-ONE Chemical Properties,Usage,Production
Synthesis
219324-21-7
193274-82-7
General procedure for the synthesis of tert-butyl 3-benzyl-4-oxopiperidine-1,3-dicarboxylate from 1-tert-butyl 3-ethyl 3-benzyl-4-oxopiperidine-1-carboxylate: the compound obtained in Method 1 (6.0 g) was dissolved in a mixture of methanol (100 mL) and 6 N hydrochloric acid (250 mL), and the reaction was stirred for 24 hours at 110 °C. Subsequently, concentrated hydrochloric acid (100 mL) was added to the reaction system and stirring was continued at 110 °C for 24 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. To the residue, 4 N aqueous sodium hydroxide solution was added to ice-cooled conditions, the pH was adjusted to alkaline, and subsequently extracted with dichloromethane. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting residue was dissolved in tetrahydrofuran (60 mL), cooled to 0 °C, and di-tert-butyl dicarbonate (5.0 mL) was added slowly, and the reaction was stirred for 1 hour at room temperature. After the reaction was completed, the solvent was removed by concentration under reduced pressure, and the residue was separated and purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4:1) to obtain tert-butyl 3-benzyl-4-oxopiperidine-1-carboxylate white crystals (4.20 g, 87% yield). Melting point: 74-75°C. 1H-NMR (CDCl3): δ 1.42 (9H, s), 2.43-2.60 (3H, m), 2.70 (1H, m), 2.97 (1H, dd, J=13.2,9.8 Hz), 3.14-3.41 (2H, m), 3.9-4.2 (2H, m), 7.15-7.35 (5H , m).
References
[1] Patent: EP1553084, 2005, A1. Location in patent: Page/Page column 54
1-BOC-3-BENZYL-PIPERIDIN-4-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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