2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Product Name: 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
CAS No.: 408492-27-3
Chemical Name: 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Synonyms: 2,6-dichloropyridine-4-borate frequency;2,6-Dichloropyridine-4-boronic acid,pinacol ester;2,6-Dichloropyridinyl-4-boronic acid pinacol ester;(2,6-DICHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2,6-DICHLORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-(2,6-Dichloro-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;Pyridine, 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH
CBNumber: CB12459531
Molecular Formula: C11H14BCl2NO2
Formula Weight: 273.95
MOL File: 408492-27-3.mol

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2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Property

Melting point:: 117-119°C
Boiling point:: 373.2±42.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
pka: -3.74±0.10(Predicted)
color: White to Almost white
InChIKey: PEFDHAOFDBNZEQ-UHFFFAOYSA-N
CAS DataBase Reference: 408492-27-3

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 739111
Product name: 2,6-Dichloropyridinyl-4-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $106
Updated: 2023/06/20

Sigma-Aldrich

Product number: 739111
Product name: 2,6-Dichloropyridinyl-4-boronic acid pinacol ester
Purity: 95%
Packaging: 250mg
Price: $34.3
Updated: 2022/05/15

TCI Chemical

Product number: D5574
Product name: 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: D5574
Product name: 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $193
Updated: 2025/07/31

TRC

Product number: D436903
Product name: 2,6-Dichloropyridine-4-boronicacid,pinacolester
Packaging: 1g
Price: $75
Updated: 2021/12/16

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2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production

Uses

2,6-Dichloropyridine-4-boronic acid, pinacol ester

Synthesis

2402-78-0

73183-34-3

408492-27-3

General procedure for the synthesis of 2,6-dichloropyridine-4-boronic acid pinacol ester from 2,6-dichloropyridine and bis-boronic acid pinacol ester: Under nitrogen protection, 2,6-dichloropyridine (3 g, 20.3 mmol), 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (5.92 g, 23.3 mmol), 1,10-phenanthroline (145 mg, 0.81 mmol) and chlorobis(1,5-cyclooctadiene)iridium(I) dimer (267 mg, 0.30 mmol) were dissolved in 1,2-dichloroethane (20 mL). After passing nitrogen for 5 minutes, the reaction mixture was heated at 100 °C for 1 hour. Upon completion of the reaction, the cooled mixture was poured into a mixture of ether (150 mL) and 4 M aqueous sodium hydroxide (200 mL) to separate the organic and aqueous phases. The aqueous phase was cooled with an ice bath and acidified with 5 M aqueous hydrochloric acid, and the resulting precipitate was filtered, washed with water and dried to afford 2,6-dichloropyridine-4-boronic acid pinacol ester (4.9 g, 17.9 mmol, 88% yield).LCMS (Method A): retention time 0.74 min; m/z 192,194 (as MH+ for boronic acid ionization).1H NMR ( 400 MHz, DMSO-d6) δ 1.28 (12H, s), 7.57 (2H, s).

References

[1] Organic Letters, 2009, vol. 11, # 16, p. 3586 - 3589
[2] Journal of the American Chemical Society, 2015, vol. 137, # 25, p. 8058 - 8061
[3] Organic and Biomolecular Chemistry, 2014, vol. 12, # 37, p. 7318 - 7327
[4] Patent: WO2011/110575, 2011, A1. Location in patent: Page/Page column 73
[5] Journal of the American Chemical Society, 2018, vol. 140, # 49, p. 17197 - 17202

2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers

Americas 1 China 119 Europe 1 India 2 Japan 2 United Kingdom 1 United States 12 Global 138

Shanghai Troedsson Technology Co., LTD

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View Lastest Price from 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 408492-27-3
Price: US $36.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 408492-27-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-06

Career Henan Chemical Co

Product: 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 408492-27-3
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

408492-27-3, 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINERelated Search:

2,6-Dichloropyridine-4-boronicacid 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-Chloropyridine-4-boronic acid pinacol ester

2,6-Dichloropyridine-4-boronic acid,pinacol ester

2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2,6-Dichloropyridinyl-4-boronic acid pinacol ester

2,6-DICHLORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

(2,6-DICHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER

Pyridine, 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(2,6-Dichloro-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH

2,6-dichloropyridine-4-borate frequency

408492-27-3

Organic boronic acid