ChemicalBook > CAS DataBase List > 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Product Name
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
CAS No.
408492-27-3
Chemical Name
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Synonyms
2,6-dichloropyridine-4-borate frequency;2,6-Dichloropyridine-4-boronic acid,pinacol ester;2,6-Dichloropyridinyl-4-boronic acid pinacol ester;(2,6-DICHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2,6-DICHLORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-(2,6-Dichloro-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;Pyridine, 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH
CBNumber
CB12459531
Molecular Formula
C11H14BCl2NO2
Formula Weight
273.95
MOL File
408492-27-3.mol
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2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Property

Melting point:
117-119°C
Boiling point:
373.2±42.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder to crystal
pka
-3.74±0.10(Predicted)
color 
White to Almost white
InChIKey
PEFDHAOFDBNZEQ-UHFFFAOYSA-N
CAS DataBase Reference
408492-27-3
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
739111
Product name
2,6-Dichloropyridinyl-4-boronic acid pinacol ester
Purity
95%
Packaging
1g
Price
$106
Updated
2023/06/20
Sigma-Aldrich
Product number
739111
Product name
2,6-Dichloropyridinyl-4-boronic acid pinacol ester
Purity
95%
Packaging
250mg
Price
$34.3
Updated
2022/05/15
TCI Chemical
Product number
D5574
Product name
2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
D5574
Product name
2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$193
Updated
2025/07/31
TRC
Product number
D436903
Product name
2,6-Dichloropyridine-4-boronicacid,pinacolester
Packaging
1g
Price
$75
Updated
2021/12/16
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2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production

Uses

2,6-Dichloropyridine-4-boronic acid, pinacol ester

Synthesis

2402-78-0

73183-34-3

408492-27-3

General procedure for the synthesis of 2,6-dichloropyridine-4-boronic acid pinacol ester from 2,6-dichloropyridine and bis-boronic acid pinacol ester: Under nitrogen protection, 2,6-dichloropyridine (3 g, 20.3 mmol), 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (5.92 g, 23.3 mmol), 1,10-phenanthroline (145 mg, 0.81 mmol) and chlorobis(1,5-cyclooctadiene)iridium(I) dimer (267 mg, 0.30 mmol) were dissolved in 1,2-dichloroethane (20 mL). After passing nitrogen for 5 minutes, the reaction mixture was heated at 100 °C for 1 hour. Upon completion of the reaction, the cooled mixture was poured into a mixture of ether (150 mL) and 4 M aqueous sodium hydroxide (200 mL) to separate the organic and aqueous phases. The aqueous phase was cooled with an ice bath and acidified with 5 M aqueous hydrochloric acid, and the resulting precipitate was filtered, washed with water and dried to afford 2,6-dichloropyridine-4-boronic acid pinacol ester (4.9 g, 17.9 mmol, 88% yield).LCMS (Method A): retention time 0.74 min; m/z 192,194 (as MH+ for boronic acid ionization).1H NMR ( 400 MHz, DMSO-d6) δ 1.28 (12H, s), 7.57 (2H, s).

References

[1] Organic Letters, 2009, vol. 11, # 16, p. 3586 - 3589
[2] Journal of the American Chemical Society, 2015, vol. 137, # 25, p. 8058 - 8061
[3] Organic and Biomolecular Chemistry, 2014, vol. 12, # 37, p. 7318 - 7327
[4] Patent: WO2011/110575, 2011, A1. Location in patent: Page/Page column 73
[5] Journal of the American Chemical Society, 2018, vol. 140, # 49, p. 17197 - 17202

2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers

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View Lastest Price from 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers

Henan Fengda Chemical Co., Ltd
Product
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 408492-27-3
Price
US $36.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Dideu Industries Group Limited
Product
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 408492-27-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-06
Career Henan Chemical Co
Product
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 408492-27-3
Price
US $5.50/KG
Min. Order
1KG
Purity
98%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

408492-27-3, 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINERelated Search:

2,6-Dichloropyridine-4-boronicacid 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-Chloropyridine-4-boronic acid pinacol ester

  • 2,6-Dichloropyridine-4-boronic acid,pinacol ester
  • 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
  • 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
  • 2,6-Dichloropyridinyl-4-boronic acid pinacol ester
  • 2,6-DICHLORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
  • (2,6-DICHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER
  • Pyridine, 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 2-(2,6-Dichloro-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH
  • 2,6-dichloropyridine-4-borate frequency
  • 408492-27-3
  • Organic boronic acid