3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

Product Name: 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
CAS No.: 81971-38-2
Chemical Name: 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
Synonyms: 3-bromo-1-methylpyridin-2-one;BROMO-1-METHYLPYRIDIN-2(1H)-ONE;3-Bromo-1-methyl-2(1H)-pyridinone;3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;3-Bromo-1-methyl-1H-pyridin-2-one;2(1H)-Pyridinone, 3-bromo-1-methyl-;3-bromo-1-methyl-1,2-dihydropyridin-2-one
CBNumber: CB12459632
Molecular Formula: C6H6BrNO
Formula Weight: 188.02
MOL File: 81971-38-2.mol

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3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Property

Boiling point:: 120-125 °C(Press: 0.5 Torr)
Density: 1.664±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -2.77±0.62(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C6H6BrNO/c1-8-4-2-3-5(7)6(8)9/h2-4H,1H3
InChIKey: HKLQWLOMEUJSOR-UHFFFAOYSA-N
SMILES: C1(=O)N(C)C=CC=C1Br

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B681938
Product name: 3-Bromo-1-methylpyridin-2(1H)-one
Packaging: 100mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0620623
Product name: 3-BROMO-1-METHYL-1,2-DIHYDROPYRIDIN-2-ONE
Purity: 95.00%
Packaging: 5MG
Price: $454.9
Updated: 2021/12/16

AK Scientific

Product number: 3240AQ
Product name: 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
Packaging: 1g
Price: $726.8
Updated: 2021/12/16

Matrix Scientific

Product number: 123121
Product name: 3-Bromo-1-methylpyridin-2(1H)-one
Purity: 95+%
Packaging: 1g
Price: $1238
Updated: 2021/12/16

Ambeed

Product number: A281878
Product name: 3-Bromo-1-methylpyridin-2(1H)-one
Purity: 95%
Packaging: 100mg
Price: $47
Updated: 2021/12/16

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3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Chemical Properties,Usage,Production

Synthesis

13466-43-8

74-88-4

81971-38-2

Example 19: A mixture of 3-bromo-2-hydroxypyridine (740 mg, 4.25 mmol), potassium carbonate (1.18 g, 8.5 mmol), and iodomethane (2.65 mL, 42.5 mmol) in 1,2-dimethoxyethane (DME, 10 mL) was heated to reflux, and the reaction was carried out overnight. Upon completion of the reaction, the mixture was filtered and the solids were washed with ethyl acetate. The filtrate and washings were combined and concentrated to dryness under reduced pressure. The resulting crude product was purified by dry column chromatography on silica gel (27 g) to afford the target compound 3-bromo-1-methyl-2-pyridinone (0.63 g, 79% yield) using ethyl acetate as eluent. The product was detected by low resolution mass spectrometry (LRMS, electrospray ionization, positive ion mode) and showed a molecular ion peak m/z 188 ([M + H]+).

References

[1] Synlett, 2015, vol. 26, # 11, p. 1557 - 1562
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7076 - 7080
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 4840 - 4860
[4] Patent: US6388084, 2002, B1
[5] Patent: WO2017/197046, 2017, A1. Location in patent: Page/Page column 344; 345

3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Suppliers

China 59 India 1 United States 5 Global 65

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81971-38-2, 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONERelated Search:

3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE

3-bromo-1-methyl-1,2-dihydropyridin-2-one

3-Bromo-1-methyl-1H-pyridin-2-one

3-bromo-1-methylpyridin-2-one

2(1H)-Pyridinone, 3-bromo-1-methyl-

BROMO-1-METHYLPYRIDIN-2(1H)-ONE

3-Bromo-1-methyl-2(1H)-pyridinone

81971-38-2