ChemicalBook > CAS DataBase List > 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE

2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE

Product Name
2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
CAS No.
885618-31-5
Chemical Name
2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
Synonyms
129558;2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE;2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE-5;2-chloro-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidine-6-carbaldehyde;2-chloro-4-(4-morpholinyl)-Thieno[3,2-d]pyrimidine-6-carboxaldehyde;2-Chloro-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidine-6-carboxaldehyde;Thieno[3,2-d]pyriMidine-6-carboxaldehyde, 2-chloro-4-(4-Morpholinyl)-
CBNumber
CB12460546
Molecular Formula
C11H10ClN3O2S
Formula Weight
283.73
MOL File
885618-31-5.mol
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2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Property

Density 
1.522±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.91±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
C360490
Product name
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
Packaging
100mg
Price
$170
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC154363
Product name
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
Packaging
50mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC154363
Product name
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
Packaging
100mg
Price
$160
Updated
2021/12/16
AK Scientific
Product number
W9116
Product name
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
Packaging
100mg
Price
$217
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC154363
Product name
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
Packaging
250mg
Price
$250
Updated
2021/12/16
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2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

68-12-2

885618-31-5

The general procedure for the synthesis of 2-chloro-4-(4-morpholino)-thieno[3,2-d]pyrimidine-6-carboxaldehyde from N,N-dimethylformamide is as follows: referring to Example 3, a solution of 2-chloro-4-morpholino-4-yl-thieno[3,2-d]pyrimidine (65) (1.75 g, 6.85 mmol) in anhydrous THF (40 mL) was stirred at -78 °C. A hexane solution of 2.5 M n-butyllithium (3.3 mL, 1.2 equiv) was slowly added. The reaction mixture was continued to be stirred at -78 °C for 1 h. Anhydrous N,N-dimethylformamide (796 μL, 1.5 eq.) was added. After keeping the reaction at -78 °C for 1 h, the reaction was slowly warmed up to room temperature. Stirring was continued at room temperature for 2 h. Upon completion of the reaction, the mixture was poured into ice/water and a yellow precipitate precipitated. The precipitate was collected by filtration and air dried to afford the target product 2-chloro-4-(4-morpholino)-thieno[3,2-d]pyrimidine-6-carboxaldehyde (1.50 g, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.76 (4H, t, J = 4.9 Hz), 3.95 (4H, t, J = 4.9 Hz), 8.28 (1H, s), 10.20 (1H, s).

References

[1] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 30
[2] Patent: US2008/76768, 2008, A1. Location in patent: Page/Page column 7
[3] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 73
[4] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 63
[5] Patent: WO2007/127183, 2007, A1. Location in patent: Page/Page column 136

2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE Suppliers

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View Lastest Price from 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE manufacturers

Career Henan Chemical Co
Product
2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE 885618-31-5
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

885618-31-5, 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDERelated Search:

Morpholinazole

  • 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE
  • 2-chloro-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidine-6-carbaldehyde
  • Thieno[3,2-d]pyriMidine-6-carboxaldehyde, 2-chloro-4-(4-Morpholinyl)-
  • 2-Chloro-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidine-6-carboxaldehyde
  • 2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDINE-6-CARBALDEHYDE-5
  • 2-chloro-4-(4-morpholinyl)-Thieno[3,2-d]pyrimidine-6-carboxaldehyde
  • 129558
  • 885618-31-5
  • Heterocycle-Pyrimidine series