2-(bromomethyl)-4-phenylthiazole
- Product Name
- 2-(bromomethyl)-4-phenylthiazole
- CAS No.
- 78502-79-1
- Chemical Name
- 2-(bromomethyl)-4-phenylthiazole
- Synonyms
- 2-(bromomethyl)-4-phenylthiazole;Thiazole, 2-(broMoMethyl)-4-phenyl-;2-(BroMoMethyl)-4-phenyl-1,3-thiazole;2-Bromomethyl-4-phenylthiazole, 97% (H51780)
- CBNumber
- CB12470231
- Molecular Formula
- C10H8BrNS
- Formula Weight
- 254.15
- MOL File
- 78502-79-1.mol
2-(bromomethyl)-4-phenylthiazole Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- CAS DataBase Reference
- 78502-79-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB144144
- Product name
- 2-(Bromomethyl)-4-phenylthiazole
- Packaging
- 1g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 2289AC
- Product name
- 2-(Bromomethyl)-4-phenylthiazole
- Packaging
- 1g
- Price
- $423
- Updated
- 2021/12/16
- Product number
- FB144144
- Product name
- 2-(Bromomethyl)-4-phenylthiazole
- Packaging
- 2g
- Price
- $481
- Updated
- 2021/12/16
- Product number
- HCH0363345
- Product name
- 2-(BROMOMETHYL)-4-PHENYLTHIAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.52
- Updated
- 2021/12/16
- Product number
- 2289AC
- Product name
- 2-(Bromomethyl)-4-phenylthiazole
- Packaging
- 2g
- Price
- $699
- Updated
- 2021/12/16
2-(bromomethyl)-4-phenylthiazole Chemical Properties,Usage,Production
Synthesis
65384-99-8
78502-79-1
General procedure for the synthesis of 2-bromomethyl-4-phenylthiazole from 4-phenyl-2-hydroxymethylthiazole: (4-phenylthiazol-2-yl)methanol (Example 4C, 0.530 g, 2.77 mmol) was dissolved in dichloromethane (10 mL) and cooled to 0°C (ice bath). Phosphorus tribromide (0.118 mL, 1.247 mmol) was added dropwise over 2 min, and a thick white gel formed immediately.After 10 min, the ice bath was removed and the reaction mixture was stirred for 4 h at 22°C. Upon completion of the reaction, the reaction was quenched with ice (~10 g) and the mixture was poured into a mixture of ethyl acetate (150 mL) and saturated sodium bicarbonate solution (50 mL). The organic phase was separated, washed with brine, dried over anhydrous magnesium sulfate and subsequently concentrated under vacuum. The solid residue obtained was purified by silica gel column chromatography (2.5 x 6 cm, toluene as eluent) to afford the target product 2-bromomethyl-4-phenylthiazole (0.561 g, 80% yield) as a light yellow oil, which solidified to a light yellow solid in the refrigerator.LC (Method C): retention time 2.062 min.HRMS (ESI) calculated value C10H9BrSNa [M+Na]+ m/z 253.9634, measured value 253.9655. 1H NMR (CDCl3, 400 MHz) δ ppm: 4.81 (s, 2H), 7.34-7.39 (m, 1H), 7.41-7.47 (m, 2H), 7.52 (s, 1H), 7.86-7.92 (m , 2H).
References
[1] Patent: WO2013/163279, 2013, A1. Location in patent: Paragraph 00150
[2] Acta Chemica Scandinavica (1947-1973), 1953, vol. 7, p. 885,887
[3] Journal of the American Chemical Society, 1931, vol. 53, p. 1470,1472
[4] Patent: US2013/289238, 2013, A1. Location in patent: Page/Page column
2-(bromomethyl)-4-phenylthiazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-(bromomethyl)-4-phenylthiazole Suppliers
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- sales@carbosynth.com
- Country
- United Kingdom
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View Lastest Price from 2-(bromomethyl)-4-phenylthiazole manufacturers
- Product
- 2-(bromomethyl)-4-phenylthiazole 78502-79-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20