ChemicalBook > CAS DataBase List > tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
- Product Name
- tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
- CAS No.
- 392331-66-7
- Chemical Name
- tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
- Synonyms
- 1-Boc-4-(Aminomethyl);1-Boc-4-aMinoMethyl-4-hyd...;4-Aminomethyl-1-Boc-piperidin-4-ol;4-Aminomethyl-1-Boc-4-hydroxypiperidine,97%;4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97%;tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate;tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95%;4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester
- CBNumber
- CB12470392
- Molecular Formula
- C11H22N2O3
- Formula Weight
- 230.3
- MOL File
- 392331-66-7.mol
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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Property
- Boiling point:
- 341.0±27.0 °C(Predicted)
- Density
- 1.124
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.48±0.20(Predicted)
- form
- Solid
- color
- Off-white
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C11H22N2O3/c1-10(2,3)16-9(14)13-6-4-11(15,8-12)5-7-13/h15H,4-8,12H2,1-3H3
- InChIKey
- XYWCDAFPRBDRER-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(CN)(O)CC1
- CAS DataBase Reference
- 392331-66-7
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Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- B809728
- Product name
- tert-Butyl4-(Aminomethyl)-4-hydroxypiperidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 047363
- Product name
- tert-Butyl 4-(aminomethyl)-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- HTS028901
- Product name
- tert-butyl4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
- Packaging
- 20mg
- Price
- $89
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 047363
- Product name
- tert-Butyl 4-(aminomethyl)-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H56-1-NE
- Product name
- 1-Boc-4-aminomethyl-4-hydroxypiperidine
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Chemical Properties,Usage,Production
Uses
4-Aminomethyl-1-Boc-4-hydroxypiperidine can be used in agrochemical, pharmaceutical and dyestuff.
Synthesis
147804-30-6
392331-66-7
General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate from tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate: In a 100 mL sealed tube, a magnetic stirring bar, tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (300 mg, 1.28 mmol) and 7 M ammonium hydroxide in a methanol solution (20 mL). The reaction mixture was placed in an oil bath at 80°C and stirred for 16 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by concentration under reduced pressure to afford the crude product tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate (350 mg, >95% yield), which could be used in the subsequent reaction without further purification.LCMS (ESI) m/z 231 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7458 - 7461
[2] Patent: US2016/185786, 2016, A1. Location in patent: Paragraph 0679
[3] Patent: WO2015/92804, 2015, A1. Location in patent: Page/Page column 21
[4] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 289 - 301
[5] Patent: WO2014/147636, 2014, A1. Location in patent: Page/Page column 35; 36
tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27
Career Henan Chemical Co
- Product
- tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19
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