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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Product Name
tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
CAS No.
392331-66-7
Chemical Name
tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
Synonyms
1-Boc-4-(Aminomethyl);1-Boc-4-aMinoMethyl-4-hyd...;4-Aminomethyl-1-Boc-piperidin-4-ol;4-Aminomethyl-1-Boc-4-hydroxypiperidine,97%;4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97%;tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate;tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95%;4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester
CBNumber
CB12470392
Molecular Formula
C11H22N2O3
Formula Weight
230.3
MOL File
392331-66-7.mol
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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Property

Boiling point:
341.0±27.0 °C(Predicted)
Density 
1.124
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.48±0.20(Predicted)
form 
Solid
color 
Off-white
Water Solubility 
Slightly soluble in water.
Sensitive 
Air Sensitive
InChI
InChI=1S/C11H22N2O3/c1-10(2,3)16-9(14)13-6-4-11(15,8-12)5-7-13/h15H,4-8,12H2,1-3H3
InChIKey
XYWCDAFPRBDRER-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(CN)(O)CC1
CAS DataBase Reference
392331-66-7
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B809728
Product name
tert-Butyl4-(Aminomethyl)-4-hydroxypiperidine-1-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
047363
Product name
tert-Butyl 4-(aminomethyl)-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate
Purity
>95%
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
HTS028901
Product name
tert-butyl4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
Packaging
20mg
Price
$89
Updated
2021/12/16
Matrix Scientific
Product number
047363
Product name
tert-Butyl 4-(aminomethyl)-4-hydroxytetrahydro-1(2H)-pyridinecarboxylate
Purity
>95%
Packaging
1g
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-NE
Product name
1-Boc-4-aminomethyl-4-hydroxypiperidine
Packaging
1g
Price
$98
Updated
2021/12/16
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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

4-Aminomethyl-1-Boc-4-hydroxypiperidine can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

147804-30-6

392331-66-7

General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate from tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate: In a 100 mL sealed tube, a magnetic stirring bar, tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (300 mg, 1.28 mmol) and 7 M ammonium hydroxide in a methanol solution (20 mL). The reaction mixture was placed in an oil bath at 80°C and stirred for 16 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by concentration under reduced pressure to afford the crude product tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate (350 mg, >95% yield), which could be used in the subsequent reaction without further purification.LCMS (ESI) m/z 231 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7458 - 7461
[2] Patent: US2016/185786, 2016, A1. Location in patent: Paragraph 0679
[3] Patent: WO2015/92804, 2015, A1. Location in patent: Page/Page column 21
[4] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 289 - 301
[5] Patent: WO2014/147636, 2014, A1. Location in patent: Page/Page column 35; 36

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Suppliers

China 89 Germany 1 India 4 United Kingdom 2 United States 9 Global 105
Arasan Chemicals Private Limited
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India
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Alfa Aesar
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India
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A.J Chemicals
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sales@ajchem.in
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India
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View Lastest Price from tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-27
Career Henan Chemical Co
Product
tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500kg
Release date
2018-08-19

392331-66-7, tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylateRelated Search:

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  • 392331-66-7