ChemicalBook > CAS DataBase List > (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

Product Name
(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
CAS No.
481704-21-6
Chemical Name
(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
Synonyms
(2R,4S);H-D-Hyp-OMe.HCl;H-D-trans-Hyp-OMe.HCl;Trans-4-HYDROXY-D-PROLINE METHYL ESTER;(S)-4-HYDROXY-D-PROLINE METHYL ESTER HCL;D-Proline-4-hydroxyMethylester hydrochloride (4S);(4S)-D-Proline-4-hydroxyMethylester hydrochloride;(S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride;(4S)-4-Hydroxy-D-proline Methyl ester hydrochloride;rans-4-Hydroxy-D-proline methyl ester hydrochloride
CBNumber
CB12470822
Molecular Formula
C6H12ClNO3
Formula Weight
181.62
MOL File
481704-21-6.mol
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(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
White to off white
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
H952388
Product name
(4S)-4-Hydroxy-D-prolinemethylesterhydrochloride
Packaging
250mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-W006629
Product name
(2R,4S)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Purity
≥98.0%
Packaging
1g
Price
$55
Updated
2021/12/16
Apolloscientific
Product number
OR17882
Product name
Methyl(2R,4S)-4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging
250mg
Price
$35
Updated
2021/12/16
AK Scientific
Product number
W6475
Product name
(2R,4S)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging
250mg
Price
$38
Updated
2021/12/16
SynQuest Laboratories
Product number
4H29-5-X2
Product name
Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
Packaging
250mg
Price
$39
Updated
2021/12/16
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(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Chemical Properties,Usage,Production

Uses

(4S)-4-Hydroxy-D-proline methyl ester, HCl

Synthesis

3398-22-9

481704-21-6

(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (1; 10 g, 76.3 mmol) was used as raw material and dissolved in 200 mL of methanol. Under stirring conditions, acetyl chloride (7.6 mL, 106.8 mmol) was slowly added, followed by heating the reaction mixture to reflux overnight. Upon completion of the reaction, the mixture was cooled to room temperature and 500 mL of ether was added to induce crystallization. The white crystals formed were collected by filtration and dried under vacuum to ultimately afford methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (Compound 2; 12.7 g, 87.6% yield).

IC 50

Non-cleavable Linker

References

[1] Patent: WO2003/104249, 2003, A1. Location in patent: Page 14

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride manufacturers

Career Henan Chemical Co
Product
(2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride 481704-21-6
Price
US $2.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100kg
Release date
2019-12-20

481704-21-6, (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochlorideRelated Search:


  • (2S,4R)-Methyl 4-hydro×ypyrrolidine-2-carbo×ylate hydrochloride
  • (4S)-4-Hydroxy-D-proline Methyl ester hydrochloride
  • (4S)-D-Proline-4-hydroxyMethylester hydrochloride
  • (S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride
  • Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
  • D-Proline-4-hydroxyMethylester hydrochloride (4S)
  • trans-4-Hydroxy-D-proline methyl ester hydrochloride, (2R,4S)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride
  • D-Proline, 4-hydroxy-, Methyl ester, hydrochloride (1:1), (4S)-
  • 4-hydroxy-1-Methylpyrrolidine-2-carboxylate hydrochloride
  • H-D-trans-Hyp-OMe.HCl
  • (S)-4-HYDROXY-D-PROLINE METHYL ESTER HCL
  • (2R,4S)
  • (2R,4S)-trans-4-hydroxy-D-proline methyl ester hydrochloride
  • (2S,4R)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidinium chloride
  • TRANS-4-HYDROXY-D-PROLINE METHYL ESTER HYDROCHLORIDE
  • (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride USP/EP/BP
  • tans-4-Hydroxy-D-proline methyl ester (hydrochloride)
  • (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochlorid
  • rans-4-Hydroxy-D-proline methyl ester hydrochloride
  • (4S)-4-hydroxy-D-Proline methyl ester hydrochloride (1:1)
  • (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride H-Hyp-OMe.HCl
  • Trans-4-HYDROXY-D-PROLINE METHYL ESTER
  • H-D-Hyp-OMe.HCl
  • (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/Trans-4-HYDROXY-D-PROLINE METHYL ESTER Hydrochloride
  • 481704-21-6