(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

Product Name: (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
CAS No.: 481704-21-6
Chemical Name: (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
Synonyms: (2R,4S);H-D-Hyp-OMe.HCl;H-D-trans-Hyp-OMe.HCl;Trans-4-HYDROXY-D-PROLINE METHYL ESTER;(S)-4-HYDROXY-D-PROLINE METHYL ESTER HCL;D-Proline-4-hydroxyMethylester hydrochloride (4S);(4S)-D-Proline-4-hydroxyMethylester hydrochloride;(S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride;(4S)-4-Hydroxy-D-proline Methyl ester hydrochloride;rans-4-Hydroxy-D-proline methyl ester hydrochloride
CBNumber: CB12470822
Molecular Formula: C6H12ClNO3
Formula Weight: 181.62
MOL File: 481704-21-6.mol

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(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: White to off white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: H952388
Product name: (4S)-4-Hydroxy-D-prolinemethylesterhydrochloride
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: OR17882
Product name: Methyl(2R,4S)-4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging: 250mg
Price: $35
Updated: 2021/12/16

AK Scientific

Product number: W6475
Product name: (2R,4S)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging: 250mg
Price: $38
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-5-X2
Product name: Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
Packaging: 250mg
Price: $39
Updated: 2021/12/16

ChemScene

Product number: CS-W006629
Product name: (2R,4S)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Purity: ≥98.0%
Packaging: 1g
Price: $55
Updated: 2021/12/16

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(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Chemical Properties,Usage,Production

Uses

(4S)-4-Hydroxy-D-proline methyl ester, HCl

Synthesis

3398-22-9

481704-21-6

(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid (1; 10 g, 76.3 mmol) was used as raw material and dissolved in 200 mL of methanol. Under stirring conditions, acetyl chloride (7.6 mL, 106.8 mmol) was slowly added, followed by heating the reaction mixture to reflux overnight. Upon completion of the reaction, the mixture was cooled to room temperature and 500 mL of ether was added to induce crystallization. The white crystals formed were collected by filtration and dried under vacuum to ultimately afford methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (Compound 2; 12.7 g, 87.6% yield).

IC 50

Non-cleavable Linker

References

[1] Patent: WO2003/104249, 2003, A1. Location in patent: Page 14

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride Suppliers

China 104 India 4 United Kingdom 1 United States 10 Global 119

Beijing Hezhicheng Chemical Products Co., Ltd

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View Lastest Price from (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride manufacturers

Career Henan Chemical Co

Product: (2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride 481704-21-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 100kg
Release date: 2019-12-20

481704-21-6, (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochlorideRelated Search:

(2S,4R)-Methyl 4-hydro×ypyrrolidine-2-carbo×ylate hydrochloride

(4S)-4-Hydroxy-D-proline Methyl ester hydrochloride

(4S)-D-Proline-4-hydroxyMethylester hydrochloride

(S)-4-Hydroxy-D-proline Methyl Ester Hydrochloride

Methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

D-Proline-4-hydroxyMethylester hydrochloride (4S)

trans-4-Hydroxy-D-proline methyl ester hydrochloride, (2R,4S)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride

D-Proline, 4-hydroxy-, Methyl ester, hydrochloride (1:1), (4S)-

4-hydroxy-1-Methylpyrrolidine-2-carboxylate hydrochloride

H-D-trans-Hyp-OMe.HCl

(S)-4-HYDROXY-D-PROLINE METHYL ESTER HCL

(2R,4S)

(2R,4S)-trans-4-hydroxy-D-proline methyl ester hydrochloride

(2S,4R)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidinium chloride

TRANS-4-HYDROXY-D-PROLINE METHYL ESTER HYDROCHLORIDE

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride USP/EP/BP

tans-4-Hydroxy-D-proline methyl ester (hydrochloride)

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochlorid

rans-4-Hydroxy-D-proline methyl ester hydrochloride

(4S)-4-hydroxy-D-Proline methyl ester hydrochloride (1:1)

(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride H-Hyp-OMe.HCl

Trans-4-HYDROXY-D-PROLINE METHYL ESTER

H-D-Hyp-OMe.HCl

(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/Trans-4-HYDROXY-D-PROLINE METHYL ESTER Hydrochloride

481704-21-6