ChemicalBook > CAS DataBase List > 5-Chloro-1,3,4-thiadiazol-2-ylamine

5-Chloro-1,3,4-thiadiazol-2-ylamine

Product Name: 5-Chloro-1,3,4-thiadiazol-2-ylamine
CAS No.: 37566-40-8
Chemical Name: 5-Chloro-1,3,4-thiadiazol-2-ylamine
Synonyms: 5-Chloro-1,3,4-thiadiazol-2-aMine;2-Amino-5-chloro-1,3,4-thiadiazole;1,3,4-Thiadiazol-2-amine, 5-chloro-;5-Chloro-1,3,4-thiadiazol-2-ylamine
CBNumber: CB12471344
Molecular Formula: C2H2ClN3S
Formula Weight: 135.58
MOL File: 37566-40-8.mol

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5-Chloro-1,3,4-thiadiazol-2-ylamine Property

Melting point:: 167-169oC
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Sparingly), Methanol (Very Slightly)
form: Solid
color: White
CAS DataBase Reference: 37566-40-8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C411460
Product name: 5-Chloro-1,3,4-thiadiazol-2-amine
Packaging: 250mg
Price: $110
Updated: 2021/12/16

TRC

Product number: C411460
Product name: 5-Chloro-1,3,4-thiadiazol-2-amine
Packaging: 500mg
Price: $180
Updated: 2021/12/16

TRC

Product number: C411460
Product name: 5-Chloro-1,3,4-thiadiazol-2-amine
Packaging: 1g
Price: $275
Updated: 2021/12/16

AK Scientific

Product number: W5844
Product name: 5-Chloro-1,3,4-thiadiazol-2-amine
Packaging: 100mg
Price: $34
Updated: 2021/12/16

AK Scientific

Product number: W5844
Product name: 5-Chloro-1,3,4-thiadiazol-2-amine
Packaging: 250mg
Price: $51
Updated: 2021/12/16

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5-Chloro-1,3,4-thiadiazol-2-ylamine Chemical Properties,Usage,Production

Uses

5-Chloro-1,3,4-thiadiazol-2-amine was found to be active against several transplanted animal tumors. It can also be used to synthesize 6-fluoro-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones.

Synthesis

4005-51-0

37566-40-8

Step 4: Synthesis of 5-chloro-1,3,4-thiadiazol-2-amine To a stirred solution of 2-amino-1,3,4-thiadiazole (0.5 g, 4.95 mmol) in carbon tetrachloride (10.0 mL) was slowly added N-chlorosuccinimide (0.73 g, 5.45 mmol) at 25 °C. The reaction mixture was warmed to 85 °C and stirred continuously for 2 hours. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was quenched with ice water and the target compounds were extracted with a dichloromethane solution of 10% methanol. The organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography on silica gel (100-200 mesh) with the eluent being a hexane solution of 20% ethyl acetate to afford 5-chloro-1,3,4-thiadiazol-2-amine (0.18 g, yield 26.94%) as a light brown solid. Mass spectrum (MS): 135.97 [M+H]+.

References

[1] Patent: US2017/291894, 2017, A1. Location in patent: Paragraph 0383-0385

5-Chloro-1,3,4-thiadiazol-2-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Chloro-1,3,4-thiadiazol-2-ylamine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-1,3,4-thiadiazol-2-ylamine 37566-40-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-1,3,4-thiadiazol-2-amine 37566-40-8
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 99%+
Supply Ability: 10 tons
Release date: 2019-12-27

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-1,3,4-thiadiazol-2-amine 37566-40-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-15

37566-40-8, 5-Chloro-1,3,4-thiadiazol-2-ylamineRelated Search:

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5-Chloro-1,3,4-thiadiazol-2-ylamine

5-Chloro-1,3,4-thiadiazol-2-aMine

1,3,4-Thiadiazol-2-amine, 5-chloro-

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37566-40-8