ChemicalBook > CAS DataBase List > a-Helical Corticotropin Releasing Factor (12-41)

a-Helical Corticotropin Releasing Factor (12-41)

Product Name
a-Helical Corticotropin Releasing Factor (12-41)
CAS No.
158535-55-8
Chemical Name
a-Helical Corticotropin Releasing Factor (12-41)
Synonyms
a-Helical CRF (12-41);α-Helical CRF (12-41);PubChem ID: 131849100;α-Helical CRF (12-41);ALFA-HELICAL CRF (12-41);α-Helical CRF (12-41) trifluoroacetate salt;12-41-Corticotropin-releasing factor(human);Alpha-Helical CRF (12-41) trifluoroacetate salt;a-Helical Corticotropin Releasing Factor (12-41);PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2
CBNumber
CB12476804
Molecular Formula
C152H251N43O47S2
Formula Weight
3497.01
MOL File
158535-55-8.mol
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a-Helical Corticotropin Releasing Factor (12-41) Property

Density 
1.45±0.1 g/cm3(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
BIO0000316
Product name
ALFA-HELICAL CRF (12-41)
Purity
95.00%
Packaging
5MG
Price
$495.07
Updated
2021/12/16
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a-Helical Corticotropin Releasing Factor (12-41) Chemical Properties,Usage,Production

Uses

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].

in vivo

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1].

Animal Model:Guinea pig pups (20-26 days old and )[1]
Dosage:15, 50, 150 μg per animal
Administration:Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min.
Result:Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups.
Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.

References

[1] Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47. DOI:10.1002/(sici)1098-2302(199707)31:1<39::aid-dev4>3.0.co;2-v
[2] Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.

a-Helical Corticotropin Releasing Factor (12-41) Preparation Products And Raw materials

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Preparation Products

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