ALPHA-HELICAL CRF (9-41)

Product Name: ALPHA-HELICAL CRF (9-41)
CAS No.: 99658-03-4
Chemical Name: ALPHA-HELICAL CRF (9-41)
Synonyms: ALPHA-HELICAL CRF (9-41);CORTICOTROPIN RELEASING FACTOR ANTAGONIST;α-Helical CRF (9-41) trifluoroacetate salt;ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR;Alpha-Helical CRF (9-41) trifluoroacetate salt;ALPHA-CORTICOTROPIN-RELEASING FACTOR 9-41, HELICAL;ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41);alpha-Helical corticotropin releasing factor fragment;α-helical corticotropin releasing factor fragment (9-41);ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR FRAGMENT (9-41)
CBNumber: CB1103870
Molecular Formula: C22H25IN2O6
Formula Weight: 540.34817
MOL File: 99658-03-4.mol

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ALPHA-HELICAL CRF (9-41) Property

storage temp.: −20°C
form: powder
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2917
Product name: Corticotropin Releasing Factor Antagonist
Purity: ≥97% (HPLC)
Packaging: 0.1mg
Price: $160
Updated: 2025/07/31

Tocris

Product number: 1184
Product name: alpha-helicalCRF9-41
Packaging: 500U
Price: $306
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364215
Product name: Alpha-Helical CRF (9-41)
Purity: > 95%
Packaging: 1mg
Price: $669.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364215
Product name: Alpha-Helical CRF (9-41)
Purity: > 95%
Packaging: 5mg
Price: $1657.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364215
Product name: Alpha-Helical CRF (9-41)
Purity: > 95%
Packaging: 10mg
Price: $2480.3
Updated: 2021/12/16

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ALPHA-HELICAL CRF (9-41) Chemical Properties,Usage,Production

Uses

α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[1][2].

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

in vivo

α-Helical Corticotropin Releasing Factor (9-41) (10 μg; the third or lateral ventricle of the brain injection; once) significantly decreases plasma GH values^[1]. α-Helical Corticotropin Releasing Factor (9-41) (100 ng/kg; i.c.v. once) affects rhlL-1/β-induced enhancement of the splenic sympathetic activity^[2].

Animal Model:	Adult Sprague-Dawley rats^[1]
Dosage:	10 μg
Administration:	The third or lateral ventricle of the brain injection; 10 μg once
Result:	Abolished the 10 min electroshocks-produced the decreasing of plasma GH levels by injected into the third or lateral ventricle of the brain 45 min before exposure to stress.

Animal Model:	Adult Sprague-Dawley rats with immunity of endogenous somatostatin (SS)^[1]
Dosage:	10 μg
Administration:	Lateral ventricle brain injection; 10 μg once
Result:	Showed no effect on plasma GH values in rats whose endogenous SS had been immunoneutralized, but did interfere with the stimulatory effect of GH-releasing factor (GRF).

Animal Model:	Male Wistar rats with rhlL-1/β injection^[2]
Dosage:	100 ng/kg
Administration:	Intracerebroventricularly injection; 100 ng/kg once
Result:	Completely blocked the rhlL-1/β-induced enhancement of the splenic sympathetic activity, but failed to alter the enhancement of nociceptive behaviors caused by rhlL-1/β.

References

[1] Rivier C, Vale W. Involvement of corticotropin-releasing factor and somatostatin in stress-induced inhibition of growth hormone secretion in the rat. Endocrinology. 1985 Dec;117(6):2478-82. DOI:10.1210/endo-117-6-2478
[2] Takakazu Oka, et al. Intracerebroventricular injection of interleukin-1/β induces hyperalgesia in rats. Brain Research, 624 (1993) 61-68.

ALPHA-HELICAL CRF (9-41) Preparation Products And Raw materials

Raw materials

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ALPHA-HELICAL CRF (9-41) Suppliers

China 43 France 1 Germany 1 Japan 1 Switzerland 1 United Kingdom 1 United States 5 Global 53

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99658-03-4, ALPHA-HELICAL CRF (9-41)Related Search:

a-Helical Corticotropin Releasing Factor (12-41) H-ALA-ARG-LEU-ASP-VAL-ALA-SER-GLU-PHE-ARG-LYS-LYS-TRP-ASN-LYS-TRP-ALA-LEU-SER-ARG-NH2 ADRENOMEDULLIN (22-52) (HUMAN) TERT-BUTYL ISOCYANIDE Ferric acetylacetonate Benzyl isocyanide METHYL ISOCYANOACETATE Tosylmethyl isocyanide Cupric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Aluminum acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III)

CORTICOTROPIN RELEASING FACTOR ANTAGONIST

H-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2

ASP-LEU-THR-PHE-HIS-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-ALA-GLU-GLN-ALA-LEU-ASN-ARG-LEU-LEU-GLU-ALA-NH2

ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2

ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR

α-helical corticotropin releasing factor fragment (9-41)

ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41)

ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR FRAGMENT (9-41)

ALPHA-HELICAL CRF (9-41)

ALPHA-CORTICOTROPIN-RELEASING FACTOR 9-41, HELICAL

alpha-Helical corticotropin releasing factor fragment

methyl (2S)-2-[[(3R)-3-hydroxy-4-(phenylmethoxycarbonylamino)butanoyl]amino]-3-(2-iodophenyl)propanoate

L-α-Aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alanine

α-Helical CRF (9-41) trifluoroacetate salt

alpha-Helical CRF (9-41) |alpha|a-Helical Corticotropin Releasing Factor (9-41)

Alpha-Helical CRF (9-41) trifluoroacetate salt

99658-03-4

C166H273N45O54S2

C22H25IN2O6

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