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2-Phenyl-2-(1-piperidinyl)propane

Product Name
2-Phenyl-2-(1-piperidinyl)propane
CAS No.
92321-29-4
Chemical Name
2-Phenyl-2-(1-piperidinyl)propane
Synonyms
PPP;Benzhexol Impurity 13;α-Dimethylbenzyl)piperidine;1-(α,α-DiMethylbenzyl)piperidine;1-(a,a-dimethylbenzyl)piperidine;2-Phenyl-2-(1-piperdinyl)propane;1-(2-Phenylpropan-2-yl)piperidine;2-phenyl-2-(1-piperidinyl)propane;1-(1-Methyl-1-phenylethyl)piperidine;Piperidine, 1-(1-methyl-1-phenylethyl)-
CBNumber
CB1247930
Molecular Formula
C14H21N
Formula Weight
203.32
MOL File
92321-29-4.mol
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2-Phenyl-2-(1-piperidinyl)propane Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Oil
color 
Colourless to Light Yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17799
Product name
2-Phenyl-2-(1-piperidinyl)propane
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17799
Product name
2-Phenyl-2-(1-piperidinyl)propane
Purity
≥95%
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
17799
Product name
2-Phenyl-2-(1-piperidinyl)propane
Purity
≥95%
Packaging
10mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
17799
Product name
2-Phenyl-2-(1-piperidinyl)propane
Purity
≥95%
Packaging
25mg
Price
$745
Updated
2024/03/01
TRC
Product number
P336010
Product name
2-Phenyl-2-(1-piperidinyl)propane
Packaging
250mg
Price
$870
Updated
2021/12/16
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2-Phenyl-2-(1-piperidinyl)propane Chemical Properties,Usage,Production

Description

2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 μM; IC50 = 5.1 μM). It is 15-fold more selective for inhibition of CYP2B6 over CYP2D6 and 40-60-fold more selective for CYP2B6 over CYP1A2, CYP2A6, CYP2Cs, and CYP3A.

Chemical Properties

Colorless to Light Yellow Oil

Uses

Enzyme inhibitor. A selective inactivator of CYP2B6.

in vitro

previous study found that 2-phenyl-2-(1-piperidinyl)propane could inactivate the 7-(benzyloxy)resorufin o-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats. the 7-ethoxy-4-(trifluoromethyl)coumarin o-deethylation activity of purified rat liver p450 2b1 and expressed human p450 2b6 was also inactivated by 2-phenyl-2-(1-piperidinyl)propane in a reconstituted system. with nadph, the loss of activity was founf to be both time- and concentration-dependent, and followed pseudo first order kinetics. the time for 50% of the p450 2b1 to become inactivated at saturating concentrations of 2-phenyl-2-(1-piperidinyl)propane was ~2.5 min. p450 2b6 was inactivated by 2-phenyl-2-(1-piperidinyl)propane with a k(inact) of 0.07 min(-1), a k(i) of 1.2 microm, and a t(1/2) of 9.5 min. the inactivated p450s 2b1 and 2b6 lost about 25 and 15%, respectively, indicating that the loss of activity was caused by a 2-phenyl-2-(1-piperidinyl)propane modification of the apoprotein rather than the heme [1].

References

[1] chun j, kent um, moss rm, sayre lm, hollenberg pf. mechanism-based inactivation of cytochromes p450 2b1 and p450 2b6 by 2-phenyl-2-(1-piperidinyl)propane. drug metab dispos. 2000 aug;28(8):905-11.

2-Phenyl-2-(1-piperidinyl)propane Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Phenyl-2-(1-piperidinyl)propane Suppliers

Canada 1 China 45 India 2 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 14 Global 67
Shanghai ZhengXia Medical Technology Co., Ltd.
Tel
13585673075
Email
317388297@qq.com
Country
China
ProdList
254
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50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@163.com
Country
China
ProdList
283
Advantage
58
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
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60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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80
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
5037
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58

92321-29-4, 2-Phenyl-2-(1-piperidinyl)propaneRelated Search:

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