1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE)

1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE) Property

storage temp. 

Inert atmosphere,Room Temperature

Appearance

White to off-white Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE) Chemical Properties,Usage,Production

Synthesis

Step 2: 1-(4-Bromophenyl)cyclobutane-1-carboxamide (8.120 g, 31.952 mmol) was dissolved in 1-butanol (50 mL), and sodium hypochlorite (11.00% aqueous, 25.101 mL, 44.733 mmol) and sodium hydroxide (3.00 M aqueous, 29.822 mL, 89.466 mmol) were added in sequence . The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The concentrate was redissolved in ethyl acetate, hydrochloric acid (4.00 M solution of 1,4-dioxane, 11.982 mL, 47.928 mmol) was added and stirred. The precipitated solid was filtered, washed with ethyl acetate and dried to give 1-(4-bromophenyl)cyclobutanamine hydrochloride (3.320 g, 39.6% yield) as a white solid.

References

[1] Patent: KR2017/43091, 2017, A. Location in patent: Paragraph 1332; 1339-11341