ChemicalBook > CAS DataBase List > 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
- Product Name
- 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
- CAS No.
- 121936-68-3
- Chemical Name
- 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
- Synonyms
- 6-Bromoisovanillic acid;2-bromo-4-methoxy-5-hydroxybenzoic acid;2-bromo-4-mehtoxyl-5-hydroxybenzoic acid,;2-AMino-5-broMo-3-difluoroMethoxypyridine;Benzoic acid, 2-bromo-5-hydroxy-4-methoxy-;2-Amino-3-Difluoromethoxy-5-Bromopyridine ;2.5.4-2 Bromo 4 methoxy 5 hydroxybenzoic acid;2-bromo-4-mehtoxyl-5-hydroxybenzoic acid ISO 9001：2015 REACH
- CBNumber
- CB12489611
- Molecular Formula
- C8H7BrO4
- Formula Weight
- 247.04
- MOL File
- 121936-68-3.mol
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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Property
- Boiling point:
- 367℃
- Density
- 1.757
- Flash point:
- 176℃
- storage temp.
- RT, stored under nitrogen
- pka
- 3.00±0.10(Predicted)
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C8H7BrO4/c1-13-7-3-5(9)4(8(11)12)2-6(7)10/h2-3,10H,1H3,(H,11,12)
- InChIKey
- QOHWIPQTBHQOQW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(O)=C(OC)C=C1Br
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Safety
- HS Code
- 2918999090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- X9509
- Product name
- 2-Amino-5-bromo-3-difluoromethoxypyridine
- Packaging
- 5g
- Price
- $172
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 090277
- Product name
- 2-Amino-5-bromo-3-difluoromethoxypyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $198
- Updated
- 2021/12/16
AK Scientific
- Product number
- X9509
- Product name
- 2-Amino-5-bromo-3-difluoromethoxypyridine
- Packaging
- 10g
- Price
- $266
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2629-9-37
- Product name
- 2-Bromo-5-hydroxy-4-methoxybenzoic acid
- Packaging
- 1g
- Price
- $437
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 090277
- Product name
- 2-Amino-5-bromo-3-difluoromethoxypyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $437
- Updated
- 2021/12/16
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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Chemical Properties,Usage,Production
Synthesis
2973-59-3
121936-68-3
The general procedure for the synthesis of 2-bromo-5-hydroxy-4-methoxybenzoic acid (B13) from 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2) is as follows: 1. 1 kg of 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2) and 1.255 kg of sulfamic acid were added to a solvent mixture containing 4.473 kg of EtOAc and 8 L of water under stirring conditions. Stirring was continued until all solids were completely dissolved. 2. Cool the reaction mixture to -10 to 0 °C. 3. In a separate vessel, an aqueous sodium chlorite solution was prepared by dissolving 505 g of sodium chlorite in 3 L of water. 4. Slowly add the sodium chlorite solution dropwise to the pre-cooled B2 solution while keeping the reaction temperature below 5 °C. 5. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 1 hour, followed by natural warming to room temperature. 6. The reaction was monitored by thin layer chromatography (TLC). 7. After completion of the reaction, the aqueous layer was separated. The aqueous layer was extracted with 1.789 kg EtOAc, the organic phases were combined and transferred to another flask. 8. EtOAc was removed by vacuum distillation at 40 °C. 9. 9. 6.92 kg of toluene was added at 30 to 40 °C, the slurry was cooled to -10 to 0 °C, and the precipitate was collected by filtration to give about 950 g (89% yield) of 2-bromo-5-hydroxy-4-methoxybenzoic acid (B13). Product characterization: 1H NMR (CDCl3) δ 3.95 (3H, s, OCH3), 7.22 (1H, s, Ar-H), 7.46 (1H, s, Ar-H).
References
[1] Patent: US2008/255347, 2008, A1. Location in patent: Page/Page column 5
2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Preparation Products And Raw materials
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View Lastest Price from 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid manufacturers
Qiuxian Baitai New Material Co., LTD
- Product
- 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid 121936-68-3
- Price
- US $25.00/g
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-12-07
Dideu Industries Group Limited
- Product
- 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid 121936-68-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
Shijiazhuang tongyang Import and Export Co., LTD
- Product
- 2-Amino-3-Difluoromethoxy-5-Bromopyridine 121936-68-3
- Price
- US $10.00/KG
- Min. Order
- 1g
- Purity
- 99
- Supply Ability
- 52ton
- Release date
- 2021-08-12