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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid

Product Name
2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
CAS No.
121936-68-3
Chemical Name
2-bromo-4-mehtoxyl-5-hydroxybenzoic acid
Synonyms
6-Bromoisovanillic acid;2-bromo-4-methoxy-5-hydroxybenzoic acid;2-bromo-4-mehtoxyl-5-hydroxybenzoic acid,;2-AMino-5-broMo-3-difluoroMethoxypyridine;Benzoic acid, 2-bromo-5-hydroxy-4-methoxy-;2-Amino-3-Difluoromethoxy-5-Bromopyridine ;2.5.4-2 Bromo 4 methoxy 5 hydroxybenzoic acid;2-bromo-4-mehtoxyl-5-hydroxybenzoic acid ISO 9001：2015 REACH
CBNumber
CB12489611
Molecular Formula
C8H7BrO4
Formula Weight
247.04
MOL File
121936-68-3.mol
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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Property

Boiling point:
367℃
Density 
1.757
Flash point:
176℃
storage temp. 
RT, stored under nitrogen
pka
3.00±0.10(Predicted)
Appearance
Off-white to gray Solid
InChI
InChI=1S/C8H7BrO4/c1-13-7-3-5(9)4(8(11)12)2-6(7)10/h2-3,10H,1H3,(H,11,12)
InChIKey
QOHWIPQTBHQOQW-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(O)=C(OC)C=C1Br
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Safety

HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
X9509
Product name
2-Amino-5-bromo-3-difluoromethoxypyridine
Packaging
5g
Price
$172
Updated
2021/12/16
Matrix Scientific
Product number
090277
Product name
2-Amino-5-bromo-3-difluoromethoxypyridine
Purity
95+%
Packaging
250mg
Price
$198
Updated
2021/12/16
AK Scientific
Product number
X9509
Product name
2-Amino-5-bromo-3-difluoromethoxypyridine
Packaging
10g
Price
$266
Updated
2021/12/16
SynQuest Laboratories
Product number
2629-9-37
Product name
2-Bromo-5-hydroxy-4-methoxybenzoic acid
Packaging
1g
Price
$437
Updated
2021/12/16
Matrix Scientific
Product number
090277
Product name
2-Amino-5-bromo-3-difluoromethoxypyridine
Purity
95+%
Packaging
1g
Price
$437
Updated
2021/12/16
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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Chemical Properties,Usage,Production

Synthesis

2973-59-3

121936-68-3

The general procedure for the synthesis of 2-bromo-5-hydroxy-4-methoxybenzoic acid (B13) from 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2) is as follows: 1. 1 kg of 2-bromo-5-hydroxy-4-methoxybenzaldehyde (B2) and 1.255 kg of sulfamic acid were added to a solvent mixture containing 4.473 kg of EtOAc and 8 L of water under stirring conditions. Stirring was continued until all solids were completely dissolved. 2. Cool the reaction mixture to -10 to 0 °C. 3. In a separate vessel, an aqueous sodium chlorite solution was prepared by dissolving 505 g of sodium chlorite in 3 L of water. 4. Slowly add the sodium chlorite solution dropwise to the pre-cooled B2 solution while keeping the reaction temperature below 5 °C. 5. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 1 hour, followed by natural warming to room temperature. 6. The reaction was monitored by thin layer chromatography (TLC). 7. After completion of the reaction, the aqueous layer was separated. The aqueous layer was extracted with 1.789 kg EtOAc, the organic phases were combined and transferred to another flask. 8. EtOAc was removed by vacuum distillation at 40 °C. 9. 9. 6.92 kg of toluene was added at 30 to 40 °C, the slurry was cooled to -10 to 0 °C, and the precipitate was collected by filtration to give about 950 g (89% yield) of 2-bromo-5-hydroxy-4-methoxybenzoic acid (B13). Product characterization: 1H NMR (CDCl3) δ 3.95 (3H, s, OCH3), 7.22 (1H, s, Ar-H), 7.46 (1H, s, Ar-H).

References

[1] Patent: US2008/255347, 2008, A1. Location in patent: Page/Page column 5

2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-bromo-4-mehtoxyl-5-hydroxybenzoic acid Suppliers

China 99 India 2 Switzerland 1 United Kingdom 1 United States 6 Global 109
SL Drugs and Pharmaceuticals Pvt. Ltd.
Tel
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Fax
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Email
enquiry@sldrugs.com
Country
India
ProdList
2683
Advantage
50
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid manufacturers

Qiuxian Baitai New Material Co., LTD
Product
2-bromo-4-mehtoxyl-5-hydroxybenzoic acid 121936-68-3
Price
US $25.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-12-07
Dideu Industries Group Limited
Product
2-bromo-4-mehtoxyl-5-hydroxybenzoic acid 121936-68-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-23
Shijiazhuang tongyang Import and Export Co., LTD
Product
2-Amino-3-Difluoromethoxy-5-Bromopyridine 121936-68-3
Price
US $10.00/KG
Min. Order
1g
Purity
99
Supply Ability
52ton
Release date
2021-08-12

121936-68-3, 2-bromo-4-mehtoxyl-5-hydroxybenzoic acidRelated Search:


  • 2-Amino-3-Difluoromethoxy-5-Bromopyridine
  • 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid,
  • 6-Bromoisovanillic acid
  • 2-AMino-5-broMo-3-difluoroMethoxypyridine
  • Benzoic acid, 2-bromo-5-hydroxy-4-methoxy-
  • 2-bromo-4-mehtoxyl-5-hydroxybenzoic acid ISO 9001：2015 REACH
  • 2.5.4-2 Bromo 4 methoxy 5 hydroxybenzoic acid
  • 2-bromo-4-methoxy-5-hydroxybenzoic acid
  • 121936-68-3
  • Heterocycle-Pyridine series