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2-PHENYL-ISONICOTINIC ACID

Product Name
2-PHENYL-ISONICOTINIC ACID
CAS No.
55240-51-2
Chemical Name
2-PHENYL-ISONICOTINIC ACID
Synonyms
2-Phenylisonicotinicaci;2-PHENYL-ISONICOTINIC ACID;2-Phenyl-4-pyridinecarboxylic acid;2-PHENYLPYRIDINE-4-CARBOXYLIC ACID;4-Pyridinecarboxylic acid, 2-phenyl-;2-Phenylpyridine-4-carboxylic acid, 4-Carboxy-2-phenylpyridine
CBNumber
CB1249787
Molecular Formula
C12H9NO2
Formula Weight
199.21
MOL File
55240-51-2.mol
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2-PHENYL-ISONICOTINIC ACID Property

Melting point:
270-271 °C
Boiling point:
478.8±33.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
1.89±0.10(Predicted)
color 
White to Orange to Green
CAS DataBase Reference
55240-51-2
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CVT00064
Product name
2-Phenylisonicotinic acid
Packaging
1g
Price
$427
Updated
2025/07/31
TCI Chemical
Product number
P2453
Product name
2-Phenylpyridine-4-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$189
Updated
2025/07/31
TRC
Product number
P399390
Product name
2-Phenylisonicotinic acid
Packaging
10mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-1B
Product name
2-Phenylisonicotinic acid
Purity
98%
Packaging
250mg
Price
$132
Updated
2021/12/16
AK Scientific
Product number
V6577
Product name
2-Phenylisonicotinic acid
Packaging
1g
Price
$232
Updated
2021/12/16
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2-PHENYL-ISONICOTINIC ACID Chemical Properties,Usage,Production

Synthesis

66572-56-3

98-80-6

55240-51-2

Under nitrogen protection, 2-bromo-4-pyridinecarboxylic acid (0.210 g, 1.040 mmol) was dissolved in degassed 1,2-dimethoxyethane (DME, 8 mL). Tetrakis(triphenylphosphine)palladium(0) (0.060 g, 0.052 mmol) was added to the solution and the reaction mixture was stirred for 15 minutes. Subsequently, aqueous potassium carbonate (4.16 mL, 8.32 mmol) and phenylboronic acid (0.171 g, 1.403 mmol) were added. The reaction mixture was refluxed at 95 °C for 18 h, after which it was cooled to room temperature. The reaction mixture was filtered through diatomaceous earth and the pH was adjusted to 3-4 with acid to precipitate a white precipitate, which was filtered and washed with water. The white powdery product 2-phenyl-pyridine-4-carboxylic acid was obtained by recrystallization from 2-methoxyethanol. Yield: 0.106 g, 57% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.44-7.60 (m, 3H), 7.71-7.86 (dd, J = 4.9, 1.5 Hz, 1H), 8.05-8.19 (m, 2H), 8.23-8.35 (t, J = 1.2 Hz, 1H), 8.79-8.93 (dd, J = 5.1, 0.8 Hz, 1H), 13.56-13.97 (s, 1H).UPLC-ESI analysis: retention time 1.37 min, m/z 200.5 [M + H]+ (purity 92%).

References

[1] Organic Letters, 2016, vol. 18, # 23, p. 6094 - 6097
[2] Patent: US2014/357650, 2014, A1. Location in patent: Paragraph 0456; 0457; 0458; 0459
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 7, p. 3053 - 3074
[4] Patent: WO2011/32269, 2011, A1. Location in patent: Page/Page column 34
[5] Patent: US2005/54627, 2005, A1. Location in patent: Page/Page column 44

2-PHENYL-ISONICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PHENYL-ISONICOTINIC ACID Suppliers

China 81 Germany 1 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 10 Global 100
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 2-PHENYL-ISONICOTINIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Phenylisonicotinic Acid 55240-51-2
Price
US $3.00-9.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
50kg
Release date
2025-07-28
Career Henan Chemical Co
Product
2-Phenylisonicotinic Acid 55240-51-2
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10
Career Henan Chemical Co
Product
2-PHENYL-ISONICOTINIC ACID 55240-51-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-08

55240-51-2, 2-PHENYL-ISONICOTINIC ACIDRelated Search:

oxycinchophen CINCHOPHEN 2-(4-CHLORO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 2-HYDROXY-6-PHENYLPYRIDINE-4-CARBOXYLIC ACID Ethyl 2-methyl-6-phenylpyridine-3-carboxylate 5-(4-Fluorophenyl)pyridine-2-carboxylic acid 2-Phenylpyridine 2-(4-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 6-CHLORO-2-(4-CHLOROPHENYL)-4-QUINOLINE CARBOXYLIC ACID 2-(3-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 2-BIPHENYL-4-YL-QUINOLINE-4-CARBOXYLIC ACID 2-(4-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER 2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 6-BROMO-2-(4-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 2-(4-METHOXY-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID 6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID 2-(4-METHOXYPHENYL)-7-METHYLQUINOLINE-4-CARBOXYLIC ACID

  • 2-PHENYLPYRIDINE-4-CARBOXYLIC ACID
  • 2-PHENYL-ISONICOTINIC ACID
  • 2-Phenyl-4-pyridinecarboxylic acid
  • 2-Phenylpyridine-4-carboxylic acid, 4-Carboxy-2-phenylpyridine
  • 4-Pyridinecarboxylic acid, 2-phenyl-
  • 2-Phenylisonicotinicaci
  • 55240-51-2
  • Carboxylic Acids
  • Pyridines
  • API intermediates
  • Carboxylic Acids