3-Fluoro-5-bromoaniline
- Product Name
- 3-Fluoro-5-bromoaniline
- CAS No.
- 134168-97-1
- Chemical Name
- 3-Fluoro-5-bromoaniline
- Synonyms
- 3-BroMo-5-fluoro-phenylaMine;5-BroMo-3-fluoroaniline;3-Fluoro-5-bromoaniline;3-Bromo-5-fluoroaniline 97%;3-Bromo-5-fluorobenzenamine;3-Bromo-5-fluoroaniline,95%;Benzenamine, 3-bromo-5-fluoro-
- CBNumber
- CB12500057
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 134168-97-1.mol
3-Fluoro-5-bromoaniline Property
- Boiling point:
- 246℃
- Density
- 1.694
- Flash point:
- 102℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.51±0.10(Predicted)
- form
- Liquid
- color
- Brown
- InChI
- InChI=1S/C6H5BrFN/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2
- InChIKey
- NGZAVSDIXFIWHJ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(F)=CC(Br)=C1
- CAS DataBase Reference
- 134168-97-1
Safety
- RIDADR
- UN2811
- HazardClass
- 6.1
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B679178
- Product name
- 3-Bromo-5-fluoroaniline
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 074376
- Product name
- 3-Bromo-5-fluoroaniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- PC49300
- Product name
- 3-Bromo-5-fluoroaniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- PC49300
- Product name
- 3-Bromo-5-fluoroaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 3630-B-X4
- Product name
- 3-Bromo-5-fluoroaniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
3-Fluoro-5-bromoaniline Chemical Properties,Usage,Production
Synthesis
807620-95-7
134168-97-1
N-(3-bromo-5-fluorophenyl)acetamide (Intermediate 181, 8.7 g, 37.4 mmol) was used as a raw material, which was dissolved in ethanol (30 mL) and then concentrated hydrochloric acid (80 mL) was slowly added. The reaction mixture was heated to 100 °C and kept for 1 h for the reaction. After completion of the reaction, the mixture was cooled to room temperature and neutralized with 5 N sodium hydroxide solution. The crude product was extracted with ethyl acetate (2 x 100 mL) and the combined organic layers were washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. Purification by silica gel column chromatography using a gradient elution with 5-10% ethyl acetate in hexane solution gave 5.3 g (75% yield) of the yellow oily target product 3-bromo-5-fluoroaniline (Intermediate 180). Mass spectrum (ES+): m/z 190, 192 ([M+H]+), molecular formula C6H5BrFN. 1H NMR (DMSO-d6) δ: 5.46-6.00 (m, 2H), 6.24-6.37 (m, 1H), 6.44-6.53 (m, 1H), 6.54-6.61 (m, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5477 - 5480
[2] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 22, p. 5061 - 5064
[3] Patent: WO2006/134378, 2006, A1. Location in patent: Page/Page column 149
3-Fluoro-5-bromoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-5-bromoaniline manufacturers
- Product
- 3-Fluoro-5-bromoaniline 134168-97-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09