2-Bromo-3-nitro-5-(trifluoromethyl)pyridine

Product Name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
CAS No.: 1214336-90-9
Chemical Name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
Synonyms: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine;Pyridine, 2-bromo-3-nitro-5-(trifluoromethyl)-
CBNumber: CB12503634
Molecular Formula: C6H2BrF3N2O2
Formula Weight: 270.99
MOL File: 1214336-90-9.mol

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2-Bromo-3-nitro-5-(trifluoromethyl)pyridine Property

Boiling point:: 243℃
Density: 1.879
Flash point:: 101℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -5.67±0.20(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B679403
Product name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 093294
Product name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
Purity: 95+%
Packaging: 250mg
Price: $473
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0363147
Product name: 2-BROMO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $500.43
Updated: 2021/12/16

Matrix Scientific

Product number: 093294
Product name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
Purity: 95+%
Packaging: 1g
Price: $975
Updated: 2021/12/16

Ambeed

Product number: A112308
Product name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 100mg
Price: $43
Updated: 2021/12/16

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2-Bromo-3-nitro-5-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

33252-64-1

1214336-90-9

General procedure for the synthesis of 2-bromo-3-nitro-5-(trifluoromethyl)pyridine from 2-hydroxy-3-nitro-5-(trifluoromethyl)pyridine: 3-nitro-5-(trifluoromethyl)pyridin-2-ol (3.12 g, 15 mmol) was dissolved in acetonitrile (25 ml) and slowly added to a solution of phosphorus tribromide (8.6 g, 30 mmol). The reaction mixture was stirred at room temperature for 12 hours and then heated to reflux for 4 hours. Upon completion of the reaction, the reaction solution was slowly poured into a rapidly stirred aqueous solution of sodium bicarbonate (11 g dissolved in 60 ml of water). The aqueous phase was extracted with dichloromethane (3 x 20 ml) and the organic phases were combined and washed sequentially with water (20 ml) and saturated sodium chloride solution (10 ml). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the target product 2-bromo-3-nitro-5-(trifluoromethyl)pyridine (2.44 g, 9.0 mmol).

References

[1] Patent: US2011/230483, 2011, A1. Location in patent: Page/Page column 32
[2] Patent: WO2013/38386, 2013, A1. Location in patent: Page/Page column 80; 81
[3] Patent: WO2013/38373, 2013, A1. Location in patent: Page/Page column 52
[4] Patent: WO2013/38378, 2013, A1. Location in patent: Page/Page column 48
[5] Patent: WO2013/38381, 2013, A1. Location in patent: Page/Page column 50

2-Bromo-3-nitro-5-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-3-nitro-5-(trifluoromethyl)pyridine Suppliers

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1214336-90-9, 2-Bromo-3-nitro-5-(trifluoromethyl)pyridineRelated Search:

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2-Bromo-3-nitro-5-(trifluoromethyl)pyridine

Pyridine, 2-bromo-3-nitro-5-(trifluoromethyl)-

1214336-90-9

C6H2BrF3N2O2