3-bromopyrrolidin-2-one

Product Name: 3-bromopyrrolidin-2-one
CAS No.: 40557-20-8
Chemical Name: 3-bromopyrrolidin-2-one
Synonyms: 3-BroMo-2-pyrrolidone;3-broMo-2-Pyrrolidinone;3-bromopyrrolidin-2-one;alpha-Bromobutyrolactam;2-Pyrrolidinone, 3-broMo-
CBNumber: CB12506064
Molecular Formula: C4H6BrNO
Formula Weight: 164
MOL File: 40557-20-8.mol

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3-bromopyrrolidin-2-one Property

Melting point:: 83 °C
Boiling point:: 305.8±35.0 °C(Predicted)
Density: 1.715±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 14.70±0.40(Predicted)
Appearance: White to light yellow Solid

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Safety

HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B427440
Product name: 3-bromopyrrolidin-2-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B427440
Product name: 3-bromopyrrolidin-2-one
Packaging: 100mg
Price: $240
Updated: 2021/12/16

Matrix Scientific

Product number: 133916
Product name: 3-Bromopyrrolidin-2-one
Purity: 95%+
Packaging: 100mg
Price: $126
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-9-0N
Product name: 3-Bromopyrrolidin-2-one
Packaging: 100mg
Price: $340
Updated: 2021/12/16

Matrix Scientific

Product number: 133916
Product name: 3-Bromopyrrolidin-2-one
Purity: 95%+
Packaging: 500mg
Price: $402
Updated: 2021/12/16

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3-bromopyrrolidin-2-one Chemical Properties,Usage,Production

Synthesis

59882-37-0

40557-20-8

(1) Synthesis of 2-bromo-4-butyrolactam: Referring to the method of Example 6, 2,4-dibromobutyryl bromide was used as a raw material, and ammonia was used instead of 40% aqueous methylamine solution. 73.5 g (0.30 mol) of 2,4-dibromobutyric acid was converted to the amide (melting point 79 °C; 63% yield) to give a crystalline product. The crystals were dissolved in 650 g of THF (Guaranteed Reagent; manufactured by JUNSEI CHEMICAL Co., Ltd.). The reaction solution was cooled in an ice bath to a temperature below 100 °C, followed by the slow addition of 24 g (0.60 mol) of mineral oil 60% NaH (manufactured by JUNSEI CHEMICAL Co., Ltd.) over about 15 min. After the addition was completed, the reaction solution was warmed up to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the reaction solution was evaporated and concentrated to about one-third of the original volume, and then the concentrate was poured into 360 g of an ice-water mixture. The resulting mixture was extracted with 360 g of chloroform. The chloroform phase was collected, evaporated and concentrated, and purified by silica gel column chromatography to give 37.9 g (0.23 mol) of 2-bromo-4-butyrolactam (27% yield).

References

[1] Tetrahedron Asymmetry, 2003, vol. 14, # 17, p. 2587 - 2594
[2] Patent: WO2007/139215, 2007, A1. Location in patent: Page/Page column 49-50
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 11, p. 1995 - 1998
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 9, p. 1864 - 1871
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 10, p. 2016 - 2023

3-bromopyrrolidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-bromopyrrolidin-2-one Suppliers

China 25 United Kingdom 1 United States 3 Global 29

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3-bromopyrrolidin-2-one

3-BroMo-2-pyrrolidone

3-broMo-2-Pyrrolidinone

2-Pyrrolidinone, 3-broMo-

alpha-Bromobutyrolactam

40557-20-8