3-bromopyrrolidin-2-one
- Product Name
- 3-bromopyrrolidin-2-one
- CAS No.
- 40557-20-8
- Chemical Name
- 3-bromopyrrolidin-2-one
- Synonyms
- 3-BroMo-2-pyrrolidone;3-broMo-2-Pyrrolidinone;3-bromopyrrolidin-2-one;alpha-Bromobutyrolactam;2-Pyrrolidinone, 3-broMo-
- CBNumber
- CB12506064
- Molecular Formula
- C4H6BrNO
- Formula Weight
- 164
- MOL File
- 40557-20-8.mol
3-bromopyrrolidin-2-one Property
- Melting point:
- 83 °C
- Boiling point:
- 305.8±35.0 °C(Predicted)
- Density
- 1.715±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 14.70±0.40(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2933790090
N-Bromosuccinimide Price
- Product number
- B427440
- Product name
- 3-bromopyrrolidin-2-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B427440
- Product name
- 3-bromopyrrolidin-2-one
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 133916
- Product name
- 3-Bromopyrrolidin-2-one
- Purity
- 95%+
- Packaging
- 100mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 4H48-9-0N
- Product name
- 3-Bromopyrrolidin-2-one
- Packaging
- 100mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 133916
- Product name
- 3-Bromopyrrolidin-2-one
- Purity
- 95%+
- Packaging
- 500mg
- Price
- $402
- Updated
- 2021/12/16
3-bromopyrrolidin-2-one Chemical Properties,Usage,Production
Synthesis
59882-37-0
40557-20-8
(1) Synthesis of 2-bromo-4-butyrolactam: Referring to the method of Example 6, 2,4-dibromobutyryl bromide was used as a raw material, and ammonia was used instead of 40% aqueous methylamine solution. 73.5 g (0.30 mol) of 2,4-dibromobutyric acid was converted to the amide (melting point 79 °C; 63% yield) to give a crystalline product. The crystals were dissolved in 650 g of THF (Guaranteed Reagent; manufactured by JUNSEI CHEMICAL Co., Ltd.). The reaction solution was cooled in an ice bath to a temperature below 100 °C, followed by the slow addition of 24 g (0.60 mol) of mineral oil 60% NaH (manufactured by JUNSEI CHEMICAL Co., Ltd.) over about 15 min. After the addition was completed, the reaction solution was warmed up to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the reaction solution was evaporated and concentrated to about one-third of the original volume, and then the concentrate was poured into 360 g of an ice-water mixture. The resulting mixture was extracted with 360 g of chloroform. The chloroform phase was collected, evaporated and concentrated, and purified by silica gel column chromatography to give 37.9 g (0.23 mol) of 2-bromo-4-butyrolactam (27% yield).
References
[1] Tetrahedron Asymmetry, 2003, vol. 14, # 17, p. 2587 - 2594
[2] Patent: WO2007/139215, 2007, A1. Location in patent: Page/Page column 49-50
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 11, p. 1995 - 1998
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 9, p. 1864 - 1871
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 10, p. 2016 - 2023
3-bromopyrrolidin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
3-bromopyrrolidin-2-one Suppliers
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- United States
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