ChemicalBook > CAS DataBase List > 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

Product Name
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
CAS No.
1125812-58-9
Chemical Name
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
Synonyms
1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one;afoxolaner-002;afoxolaner Impurity 6;1-[3-Chloro-5-trifluoromethylphenyl;2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone;3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone;3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone;3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone;1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone;Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-
CBNumber
CB12514588
Molecular Formula
C9H3ClF6O
Formula Weight
276.56
MOL File
1125812-58-9.mol
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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Property

Boiling point:
203℃
Density 
1.512
Flash point:
77℃
storage temp. 
2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS146793
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95%
Packaging
1g
Price
$120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0361882
Product name
1-(3-CHLORO-5-(TRIFLUOROMETHYL)PHENYL)-2,2,2-TRIFLUOROETHANONE
Purity
95.00%
Packaging
0.25G
Price
$243
Updated
2021/12/16
Ambeed
Product number
A744788
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95+%
Packaging
100mg
Price
$21
Updated
2021/12/16
Ambeed
Product number
A744788
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95+%
Packaging
250mg
Price
$28
Updated
2021/12/16
Ambeed
Product number
A744788
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95+%
Packaging
1g
Price
$79
Updated
2021/12/16
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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Chemical Properties,Usage,Production

Uses

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


Cool the solution containing compound III (74.4g, 0.255mol containing compound III) to -100, and add 120g of sulfuric acid with a mass fraction of 92.5% to the above system while keeping the temperature below 0. After acidification, continue to react and keep for 1.5h, and then add 126.7g of 33% sodium nitrite aqueous solution (containing diazotizing reagent sodium nitrite 0.612mol) into the system uniformly within 2h, and keep the temperature at 0 The following reaction is carried out for 2 hours, and the system is heated to room temperature after full reaction, 111.1 g of 50% hypophosphorous acid and 0.67 g of cuprous oxide are added, and the reaction is stirred for 2 hours while keeping temperature. After the reaction is over, stand to separate the layers, and wash the organic layer with a 5% sodium bicarbonate aqueous solution, dry with anhydrous magnesium sulfate, and rectify to obtain a clear and transparent oily liquid 1-[3-chloro-5-(trifluoromethyl) (Yl)phenyl]-2,2,2-trifluoroethanone 66.9, content 99.5%, yield 87.2%.

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Suppliers

Shandong Yizhi Medical Technology Co., LTD
Tel
13287715206 15508629772
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2786175817@qq.com
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China
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Guangzhou Leiming Pharmaceutical Technology Co., Ltd
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15360509991
Email
605501357@qq.com
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China
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58
Henan Dongyao Pharmaceutical Technology Co., Ltd
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18519331287
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1751713684@qq.com
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China
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202
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HANGZHOU LOOP BIOTECH CO., LTD.
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057185260761 13396556070
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sales@looppharm.com
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China
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Changzhou Yuanhe Biopharmaceutical Co., Ltd
Tel
15995091686
Email
15995091686@163.com
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China
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Shandong Zhishang Chemical Co. LTD
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15689709505 15508639737
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2138533552@qq.com
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China
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Shandong Chenxi Pharmaceutical Co., Ltd.
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+86-0531-88803416 13153166250
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0531-88803416
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sales@chemedpharma.com
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China
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Jinan Hongkangda Chemical Co., Ltd
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0531-88901705 18753193522
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810353473@qq.com
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China
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wuxilvhuyuanshengwukejiyouxiangongsi
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0813-18681388 18681388385
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wjf18861661468@petalmial.com
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China
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Beijing Huikang Boyuan Chemical Tech Co., Ltd
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010-68862197 13810598707
Fax
010-68882204
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sales@huikangchem.com
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China
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View Lastest Price from 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone manufacturers

Hangzhou ICH Biofarm Co., Ltd
Product
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone 1125812-58-9
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
98.0% min
Supply Ability
1ton/month
Release date
2023-06-09
Career Henan Chemical Co
Product
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone 1125812-58-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-14

1125812-58-9, 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanoneRelated Search:


  • 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
  • 3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone
  • 2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone
  • 3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone
  • 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one
  • Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-
  • 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one (Afoxolaner intermediate)
  • 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone ISO 9001:2015 REACH
  • afoxolaner-002
  • afoxolaner Impurity 6
  • 1-[3-Chloro-5-trifluoromethylphenyl
  • 3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone
  • 1125812-58-9
  • 1123812-58-9