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HNHA

Product Name
HNHA
CAS No.
926908-04-5
Chemical Name
HNHA
Synonyms
HNHA;HNHAHDAC inhibitor;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
CBNumber
CB12514669
Molecular Formula
C17H21NO2S
Formula Weight
303.42
MOL File
926908-04-5.mol
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HNHA Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form 
Crystalline solid
color 
White to off-white
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64917
Product name
HNHA
Packaging
10mg
Price
$167
Updated
2021/12/16
Cayman Chemical
Product number
13295
Product name
HNHA
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
13295
Product name
HNHA
Purity
≥98%
Packaging
10mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
13295
Product name
HNHA
Purity
≥98%
Packaging
25mg
Price
$374
Updated
2024/03/01
AK Scientific
Product number
1789AH
Product name
HNHA
Packaging
25mg
Price
$513
Updated
2021/12/16
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HNHA Chemical Properties,Usage,Production

Description

HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~ 7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.

Uses

A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity

Definition

ChEBI: N-hydroxy-7-(2-naphthalenylthio)heptanamide is a member of naphthalenes.

in vitro

previous study found that hnha was able to inhibit in-vitro hdac enzyme activity as well as proliferation of human fibrosarcoma cells (ht1080). in addition, treatment of cells with hnha could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of ht1080 cell invasion [1].

in vivo

the effects of hnha on human cancer cells bearing xenograph mice was examined. results showed that as expected, hnha could dramatically reduce tumor volume as to (vehicle) control. in addition, hnha had a stronger potency than that of saha, which implied that the pharmacological potency of hnha was better than saha in vivo [1].

IC 50

100 nm

References

1. kim, d.h.,lee, j.,kim, k.n., et al. anti-tumor activity of n-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. biochemical and biophysical research communications 356, 233-238 (2007).

HNHA Preparation Products And Raw materials

Raw materials

Preparation Products

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HNHA Suppliers

China 33 United States 7 Global 40
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Tianjin Derchemist Science & Technology Co., Ltd.
Tel
22-58627059 13920586291
Fax
022-58620305
Email
zdcomcon@126.com
Country
China
ProdList
3461
Advantage
50
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9968
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4988
Advantage
58

926908-04-5, HNHARelated Search:


  • HNHAHDAC inhibitor
  • N-hydroxy-7-(2-naphthalenylthio)-Heptanamide
  • HNHA
  • Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-
  • N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide
  • Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
  • 926908-04-5
  • Other enzyme inhibitors and activators
  • Other Enzyme Inhibitors.