HNHA
- Product Name
- HNHA
- CAS No.
- 926908-04-5
- Chemical Name
- HNHA
- Synonyms
- HNHA;HNHAHDAC inhibitor;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
- CBNumber
- CB12514669
- Molecular Formula
- C17H21NO2S
- Formula Weight
- 303.42
- MOL File
- 926908-04-5.mol
HNHA Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- Crystalline solid
- Sensitive
- Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- J64917
- Product name
- HNHA
- Packaging
- 10mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 13295
- Product name
- HNHA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 13295
- Product name
- HNHA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- 13295
- Product name
- HNHA
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
- Product number
- 1789AH
- Product name
- HNHA
- Packaging
- 25mg
- Price
- $513
- Updated
- 2021/12/16
HNHA Chemical Properties,Usage,Production
Description
HNHA is a cell-
Uses
A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity
Definition
ChEBI: N-hydroxy-7-(2-naphthalenylthio)heptanamide is a member of naphthalenes.
in vitro
previous study found that hnha was able to inhibit in-vitro hdac enzyme activity as well as proliferation of human fibrosarcoma cells (ht1080). in addition, treatment of cells with hnha could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of ht1080 cell invasion [1].
in vivo
the effects of hnha on human cancer cells bearing xenograph mice was examined. results showed that as expected, hnha could dramatically reduce tumor volume as to (vehicle) control. in addition, hnha had a stronger potency than that of saha, which implied that the pharmacological potency of hnha was better than saha in vivo [1].
IC 50
100 nm
References
1. kim, d.h.,lee, j.,kim, k.n., et al. anti-tumor activity of n-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. biochemical and biophysical research communications 356, 233-238 (2007).
HNHA Preparation Products And Raw materials
Raw materials
Preparation Products
HNHA Suppliers
- Tel
- 0330-2528181
- Fax
- 0330-2528171
- sales@vdmbio.com
- Country
- United States
- ProdList
- 510
- Advantage
- 64
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58