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HNHA

Product Name
HNHA
CAS No.
926908-04-5
Chemical Name
HNHA
Synonyms
HNHA;HNHAHDAC inhibitor;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
CBNumber
CB12514669
Molecular Formula
C17H21NO2S
Formula Weight
303.42
MOL File
926908-04-5.mol
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HNHA Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form 
Crystalline solid
color 
White to off-white
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64917
Product name
HNHA
Packaging
10mg
Price
$167
Updated
2021/12/16
Cayman Chemical
Product number
13295
Product name
HNHA
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
13295
Product name
HNHA
Purity
≥98%
Packaging
10mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
13295
Product name
HNHA
Purity
≥98%
Packaging
25mg
Price
$374
Updated
2024/03/01
ApexBio Technology
Product number
C4305
Product name
HNHA
Packaging
5mg
Price
$95
Updated
2021/12/16
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HNHA Chemical Properties,Usage,Production

Description

HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~ 7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.

Uses

A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity

Definition

ChEBI: N-hydroxy-7-(2-naphthalenylthio)heptanamide is a member of naphthalenes.

in vitro

previous study found that hnha was able to inhibit in-vitro hdac enzyme activity as well as proliferation of human fibrosarcoma cells (ht1080). in addition, treatment of cells with hnha could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of ht1080 cell invasion [1].

in vivo

the effects of hnha on human cancer cells bearing xenograph mice was examined. results showed that as expected, hnha could dramatically reduce tumor volume as to (vehicle) control. in addition, hnha had a stronger potency than that of saha, which implied that the pharmacological potency of hnha was better than saha in vivo [1].

IC 50

100 nm

References

1. kim, d.h.,lee, j.,kim, k.n., et al. anti-tumor activity of n-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. biochemical and biophysical research communications 356, 233-238 (2007).

HNHA Preparation Products And Raw materials

Raw materials

Preparation Products

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HNHA Suppliers

China 33 United States 6 Global 39
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58

926908-04-5, HNHARelated Search:


  • HNHAHDAC inhibitor
  • N-hydroxy-7-(2-naphthalenylthio)-Heptanamide
  • HNHA
  • Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-
  • N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide
  • Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
  • 926908-04-5
  • Other enzyme inhibitors and activators
  • Other Enzyme Inhibitors.