10Panx
- Product Name
- 10Panx
- CAS No.
- 955091-53-9
- Chemical Name
- 10Panx
- Synonyms
- 10Panx;Trp Arg Gln Ala Ala Phe Val Asp Ser Tyr;L-Tyrosine, L-tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-
- CBNumber
- CB12522406
- Molecular Formula
- C58H79N15O16
- Formula Weight
- 1242.36
- MOL File
- 955091-53-9.mol
10Panx Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥124.2 mg/mL in DMSO; insoluble in EtOH; ≥4.26 mg/mL in H2O with ultrasonic
- form
- solid
- pka
- 3.05±0.10(Predicted)
- Water Solubility
- Soluble to 1 mg/ml in water
N-Bromosuccinimide Price
- Product number
- SML2152
- Product name
- 10Panx1 trifluoroacetate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 1MG
- Price
- $147
- Updated
- 2024/03/01
- Product number
- T895400
- Product name
- L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosineTFASalt
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- T895400
- Product name
- L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosineTFASalt
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 254341
- Product name
- 10Panx
- Packaging
- 1mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- A2700
- Product name
- 10Panx
- Packaging
- 25mg
- Price
- $400
- Updated
- 2021/12/16
10Panx Chemical Properties,Usage,Production
Uses
L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine is a connexin mimetic peptide that inhibits pannexin-1 gap junctions.
Biological Activity
10panx is a mimetic inhibitory peptide of panx1, which is a mammalian protein ectopically expressed to function as a hemi-channel, that readily and reversibly inhibits the panx1 currents. 10panx has attracted increasing attention as it allows scientists readily and reliably to examine inhibition of panx1 in cells where efficient and consistent delivery of sirna is highly difficult. according to results of multiple previous studies, 10panx selectively inhibits p2x7r-induced dye uptake without altering other aspects of r2x7r activation and atp-evoked membrane currents, constitutive dye-uptake and hemichannel-like currents that are induced by the overexpression of panx1, and atp-mediated il-1β release.pablo pelegrin and annmarie surprenant. pannexin-1 mediates large pore formation and interleukin-1β release by the atp-gated p2x7 receptor. the embo journal (2006) 25, 5071-5082
storage
Store at -20°C
10Panx Preparation Products And Raw materials
Raw materials
Preparation Products
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