3,6-dichloropyrazine-2-carbonitrile
- Product Name
- 3,6-dichloropyrazine-2-carbonitrile
- CAS No.
- 356783-16-9
- Chemical Name
- 3,6-dichloropyrazine-2-carbonitrile
- Synonyms
- QC-100;Dichloropyrazine-Favipiravir Impurity 18;,6-Dichloropyrazine-2-carbonitrile;3,6-dichloropyrazine-2-carbonitrile;3,6-Dichloro-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 3,6-dichloro-
- CBNumber
- CB12522446
- Molecular Formula
- C5HCl2N3
- Formula Weight
- 173.99
- MOL File
- 356783-16-9.mol
3,6-dichloropyrazine-2-carbonitrile Property
- Melting point:
- 93 - 95°C
- Boiling point:
- 262.0±35.0℃ (760 Torr)
- Density
- 1.60±0.1 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 112.3±25.9℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -7.43±0.10(Predicted)
- color
- Pale Yellow to Light Yellow
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- CAS DataBase Reference
- 356783-16-9
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D476008
- Product name
- 3,6-Dichloropyrazine-2-carbonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D476008
- Product name
- 3,6-Dichloropyrazine-2-carbonitrile
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-M1937
- Product name
- 3,6-Dichloropyrazine-2-carbonitrile
- Purity
- 99.31%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- HCH0364288
- Product name
- 3,6-DICHLOROPYRAZINE-2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.93
- Updated
- 2021/12/16
- Product number
- FD141293
- Product name
- 3,6-Dichloropyrazine-2-carbonitrile
- Packaging
- 500mg
- Price
- $565
- Updated
- 2021/12/16
3,6-dichloropyrazine-2-carbonitrile Chemical Properties,Usage,Production
Uses
3,6-Dichloro-2-pyrazinecarbonitrile is useful in the production of Favipiravir (F103350) a drug that is used for the treatment of advanced Ebola virus infection in a small animal model.
Synthesis
18960-19-5
356783-16-9
1.46 g of 1,4-dioxopyrazinamide (2) was homogeneously mixed with 5 mL of chlorobenzene and 12.1 g of trichlorophosphorus. The mixture was heated to 50 °C and the reaction was stirred for 50 minutes, followed by warming to 70 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature, 1.52 g of pyridine was added, and the reaction was continued to 110 °C and maintained for 8 hours. The completion of the reaction was confirmed by TLC monitoring. The reaction mixture was evaporated to dryness under reduced pressure, washed with 5 mL of ice water and subsequently extracted with ethyl acetate (10 mL x 3). The organic phase was combined and washed twice with saturated brine. The organic phase was dried over anhydrous sodium sulfate and filtered, and the filtrate was evaporated to dryness under reduced pressure. Purification by chromatography, separation and vacuum drying gave 1.45 g of light yellow solid 3,6-dichloro-2-cyanopyrazine (3) in 52.55% yield.
References
[1] Patent: CN106478528, 2017, A. Location in patent: Paragraph 0033; 0039; 0045
[2] Patent: CN107226794, 2017, A. Location in patent: Paragraph 0039
3,6-dichloropyrazine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,6-dichloropyrazine-2-carbonitrile manufacturers
- Product
- 3,6-Dichloro-2-pyrazinecarbonitrile 356783-16-9
- Price
- US $0.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 20mt/year
- Release date
- 2022-04-14
- Product
- 3,6-dichloropyrazine-2-carbonitrile 356783-16-9
- Price
- US $10.00/KG
- Min. Order
- 25Kg/Drum
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2021-04-20
- Product
- 3,6-dichloropyrazine-2-carbonitrile 356783-16-9
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 300kg/month
- Release date
- 2020-12-16