3,6-difluoropyrazine-2-carbonitrile
- Product Name
- 3,6-difluoropyrazine-2-carbonitrile
- CAS No.
- 356783-28-3
- Chemical Name
- 3,6-difluoropyrazine-2-carbonitrile
- Synonyms
- avipravir intermediates;favipravir intermediates;Favipiravir Intermediate 1;3,6-Difluoro-2-cyanopyrazine;3,6-difluoropyrazine-2-carbonitrile;3,6-Difluoro-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 3,6-difluoro-;3,6-Difluoropyrazine-2-carbonitrile(N-2)
- CBNumber
- CB42522447
- Molecular Formula
- C5HF2N3
- Formula Weight
- 141.08
- MOL File
- 356783-28-3.mol
3,6-difluoropyrazine-2-carbonitrile Property
- Boiling point:
- 206.5±35.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -7.28±0.10(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D456098
- Product name
- 3,6-Difluoropyrazine-2-carbonitrile
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- D456098
- Product name
- 3,6-Difluoropyrazine-2-carbonitrile
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0000095
- Product name
- 3,6-Difluoropyrazine-2-carbonitrile
- Purity
- 98.77%
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 3H37-3-2J
- Product name
- 3,6-Difluoropyrazine-2-carbonitrile
- Packaging
- 250mg
- Price
- $287
- Updated
- 2021/12/16
- Product number
- PC50486
- Product name
- 3,6-Difluoropyrazine-2-carbonitrile
- Packaging
- 1g
- Price
- $337
- Updated
- 2021/12/16
3,6-difluoropyrazine-2-carbonitrile Chemical Properties,Usage,Production
Uses
3,6-difluoropyrazine-2-carbonitrile is used in multi-step synthesis of Favipiravir from Aminopyrazine.
Synthesis
1)Preparation of 1.4-dioxopyrazinamide: control temperature -5 ~ 5 , 2-cyanopyrazine 5.25g with glacial acetic acid 29.95g, 30% hydrogen peroxide 45.30g mixed well, warming to 95 , reflux reaction 22h, TLC shows no raw materials, 40 decompression spinning to remove solvents, add 15ml of water, decompression spinning, repeated a few times after the removal of glacial acetic acid Add 15 ml of water, add hot chloroform extraction (15 ml * 3), the aqueous layer spun dry under reduced pressure, 90% methanol recrystallization, filtration, filter cake vacuum drying to obtain a white powdery 1,4-dioxopyrazinamide 4.45 g, melting point greater than 300 , yield 57.43%.
2) 3,6-dichloro-2-cyanopyrazine preparation: 1.4-dioxopyrazine amide 6.20g added to the redistillation of trichlorophosphorus 24.53g mixed well, 50 stirring for 50min in the heating to 70 reaction for 1h, cooled to room temperature, and then added to the triethylamine 4.86g, add than warmed to 96 , reflux reaction for 6h, the TLC shows that the reaction is complete, the reaction is complete. Spin dry under reduced pressure, washed into 10mL ice water, ethyl acetate (15mL * 3) extraction, combined organic phase, saturated brine washed twice, the organic phase was dried over anhydrous sodium sulfate and filtered, the filtrate was spun dry under reduced pressure, column chromatography purification and separation after vacuum drying to obtain a yellowish solid 3,6-dichloro-2-cyanopyrazine 3.14g, yield 45.15%, melting point 90-91 .
3,6-difluoropyrazine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3,6-difluoropyrazine-2-carbonitrile Suppliers
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View Lastest Price from 3,6-difluoropyrazine-2-carbonitrile manufacturers
- Product
- 356783-28-3 356783-28-3
- Price
- US $500.00-460.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-06
- Product
- 3,6-difluoropyrazine-2-carbonitrile 356783-28-3
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-07-07
- Product
- 3,6-difluoropyrazine-2-carbonitrile 356783-28-3
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-06