AZM 475271

Product Name: AZM 475271
CAS No.: 476159-98-5
Chemical Name: AZM 475271
Synonyms: M 475271;AZM 475271;AZM-475271,AZM475271;AZM-475271;M475271;M-475271;N-(2-Chloro-5-methoxyphenyl)-6-methoxy;N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine;4-Quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
CBNumber: CB12535662
Molecular Formula: C23H27ClN4O3
Formula Weight: 442.94
MOL File: 476159-98-5.mol

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AZM 475271 Property

Boiling point:: 556.1±50.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:43.15(Max Conc. mg/mL);97.42(Max Conc. mM)
form: A solid
pka: 8.92±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 3963
Product name: AZM475271
Purity: ≥99%(HPLC)
Packaging: 10
Price: $271
Updated: 2021/12/16

Tocris

Product number: 3963
Product name: AZM475271
Purity: ≥99%(HPLC)
Packaging: 50
Price: $1088
Updated: 2021/12/16

TRC

Product number: A808235
Product name: AZM475271
Packaging: 1mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-3955
Product name: AZM475271
Purity: 99.94%
Packaging: 5mg
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000416
Product name: AZM-475271
Purity: 95.00%
Packaging: 5MG
Price: $499.57
Updated: 2021/12/16

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AZM 475271 Chemical Properties,Usage,Production

Uses

AZM 475271 is an src tyrosine kinase inhibitor.

Biological Activity

AZM475271 (M475271) is an orally active, potent and selective inhibitor against src family kinases src and yes (IC50 = 25 nM & 10 nM, respectively; lck/VEGFR2/EGFR/csk/FGFR1 IC50 = 0.2/0.5/0.6/7.6/∼20 μM) th at effectively suppresses src-dependent cellular signaling events (26%/48% inhibition of 50 ng/mL VEGF-induced HUVEC proliferation/migration at 100 nM; 31%/72% inhibition of 10 ng/mL VEGF-induced Flk-1/Src phosphorylation in HUVECs at 300 nM) and exbihits anticancer efficacy both in cultures (70% PC-9/30% A549 proliferation inhibition at 1 μM) and in vivo (78%/100% PC-9 tumor growth suppression in mice via 10/50 mg/kg/day p.o.).

storage

Store at RT

AZM 475271 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZM 475271 Suppliers

China 41 United Kingdom 1 United States 11 Global 53

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4587
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

476159-98-5, AZM 475271Related Search:

AZM 475271

M 475271

AZM-475271;M475271;M-475271

N-(2-Chloro-5-methoxyphenyl)-6-methoxy

4-Quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-

AZM-475271,AZM475271

N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

476159-98-5

Anticancer.